Research Topic: asthma

Emerging Allergens: How Proallergenic Activity Disrupts Epithelial Barriers [Response to Letter]

mycolabadmin

Many people with allergies or asthma don’t know what’s causing their symptoms. Researchers are investigating whether fungi that grow on plants might be responsible for some of these unknown allergies. They found that certain plant fungi can trigger allergic and inflammatory responses in animal models, suggesting they could be allergens in humans. The team plans to identify the specific fungal proteins causing these reactions to develop better allergy diagnostic tests.

Read More »

Microfungus Podosphaera fusca and the Fungus-like Organism Peronospora ficariae as Potential Inhalant Allergens in a Mouse Model of Asthma

mycolabadmin

This study investigated whether two plant parasites that cause powdery and downy mildew could trigger asthma-like reactions in mice. Researchers found that extracts from these fungi induced immune responses similar to those caused by known allergens like ovalbumin, though somewhat weaker. The results suggest these organisms should be recognized as potential sources of respiratory allergies in humans. This finding may help explain some cases of allergies where the specific cause has been difficult to identify.

Read More »

Fluconazole worsened lung inflammation, partly through lung microbiome dysbiosis in mice with ovalbumin-induced asthma

mycolabadmin

Fluconazole is an antifungal medication that works well for treating asthma caused by fungal infections, but may actually worsen asthma from other causes. In mice with allergic asthma, fluconazole killed beneficial bacteria and promoted the growth of harmful bacteria that increased inflammation. This study suggests that fluconazole should only be used for fungal-related asthma and careful monitoring is needed if used in patients with regular asthma.

Read More »
Scroll to Top