A dietary supplement combining trans-resveratrol and hesperetin activates a cellular defense mechanism called Nrf2, which increases production of an enzyme (Glo1) that helps eliminate harmful byproducts of sugar metabolism. This supplement improved multiple aspects of health in studies, including better blood sugar control, reduced inflammation, and improved liver function. The combination works better than either ingredient alone, and the trans form of resveratrol is much more effective than the cis form.