This research compared how psilocybin mushrooms and escitalopram (a common antidepressant) affect the way depressed people perceive emotions. Both treatments helped patients become better at recognizing positive facial expressions and less likely to misinterpret neutral or positive faces as negative. Interestingly, while both treatments improved emotional processing similarly, the improvements were connected to later mood improvement in different ways for each drug, suggesting they may work through somewhat different mechanisms in the brain.