therapeutic action: weak myelotoxicity compared to other immunosuppressants

Comparative proteomics reveals the mechanism of cyclosporine production and mycelial growth in Tolypocladium inflatum affected by different carbon sources

Researchers studied how different sugars (fructose and sucrose) affect a fungus’s ability to produce cyclosporine A, an important drug used after organ transplants to prevent rejection. Using advanced protein analysis techniques, they found that fructose makes the fungus better at producing the drug, while sucrose makes it grow more mycelium (fungal threads). By identifying the specific proteins involved in each process, scientists can now develop better methods to produce more of this valuable medicine.

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