Voriconazole – Page 4

Extensive and recurrent infection caused by Medicopsis romeroi in two immunocompromised patients

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This case report describes two patients with weakened immune systems who developed serious fungal skin infections caused by a rare mold called Medicopsis romeroi. Both patients underwent multiple surgeries and required extended antifungal medication treatment lasting months to years. The study demonstrates that successful treatment requires a combination approach including surgical removal of infected tissue, adjustment of immunosuppressive medications, and prolonged antifungal therapy.

COVID-19-associated Pulmonary Aspergillosis in Mechanically Ventilated Patients at 7 US Hospitals: Epidemiology and Estimated Likelihood of Invasive Pulmonary Aspergillosis—Results of the Prospective MSG-017 Study

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A fungal infection caused by Aspergillus commonly occurs in COVID-19 patients on ventilators, affecting about 7% of cases. The study found that having this infection was linked to high death rates, but it was unclear whether the fungal infection itself or the severe COVID-19 caused the deaths. Single positive test results for the fungus are not reliable for diagnosis, and antifungal drugs did not improve survival rates.

Candida krusei Empyema: A Lung Transplant Case and Systematic Review of the Literature

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Candida krusei is a dangerous yeast that causes a serious lung infection called empyema, where pus collects around the lungs. This infection is particularly difficult to treat because the yeast is resistant to common antifungal drugs like fluconazole and can form protective biofilms. This systematic review identified only ten cases of this rare infection in the medical literature, showing how uncommon but serious it is, and found that patients need aggressive treatment with multiple antifungal medications combined with surgical drainage to survive.

Consecutive non-Aspergillus Fungal Invasive Infections in Chronic Granulomatous Disease: Data from the French National Reference Center for Primary ImmunoDeficiencies and literature review

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This study examines rare but serious fungal infections in patients with chronic granulomatous disease, a genetic immune disorder. Researchers analyzed 122 cases of non-Aspergillus fungal infections from French hospitals and published literature, finding that these infections often occur despite preventive antifungal medications and are challenging to diagnose. The infections were found in the lungs most commonly but could spread to bones, brain, and other organs, with treatments including antifungal drugs, surgery, and in some cases bone marrow transplants.

Epidemiology and outcomes of Candida-associated osteoarticular infections: A multicentre retrospective study from Turkey

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Researchers in Turkey studied 73 patients with rare bone and joint infections caused by Candida fungi over 10 years. They found that about half of the infections were caused by species other than the common C. albicans, with some showing resistance to fluconazole antibiotics. Surgical procedures to clean out infected tissue significantly improved patient recovery, while patients with diabetes had worse outcomes and recovered less completely.

Deep cutaneous phaeohyphomycosis caused by Cladophialophora boppii: A case report

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A 69-year-old woman with breast cancer developed a skin infection caused by a rare fungus called Cladophialophora boppii while taking dexamethasone for cancer treatment. Doctors diagnosed the infection through skin biopsy and fungal testing, then removed the infected area surgically. After three weeks of antifungal medication (itraconazole), the infection cleared completely and did not return during four months of follow-up. This case suggests that surgery combined with short-term antifungal treatment may be sufficient for this type of infection.

Evaluation of Antifungal Activity Against Candida albicans Isolates From HIV-Positive Patients with Oral Candidiasis in a Major Referral Hospital, West Java, Indonesia

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This study examined fungal infections in HIV-positive patients’ mouths at an Indonesian hospital. Researchers identified which Candida species caused the infections and tested how well common antifungal medications worked against them. They found that while a specific antifungal drug (fluconazole) was effective in most cases, some infections showed resistance, suggesting the need for careful monitoring and personalized treatment approaches.

Geotrichosis Due to Magnusiomyces capitatus: A Severe Emerging Invasive Fungal Disease

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A 71-year-old cancer patient receiving chemotherapy developed a severe blood infection caused by a rare fungus called Magnusiomyces capitatus. This emerging fungal infection caused septic shock and multiple organ failure despite treatment with antifungal medications. The case highlights how these rare fungi can be deadly in patients with weakened immune systems and emphasizes the importance of quick, accurate identification using advanced laboratory techniques to guide treatment decisions.

The tell-tale hearts: Donor-derived invasive fungal infections among orthotopic heart transplant recipients

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This case report describes two rare instances where fungal infections were transmitted from organ donors to heart transplant recipients. One involved a Candida infection and the other involved Aspergillus fungus, both causing serious bloodstream and heart infections. The patients required extensive antifungal medications and multiple surgeries to survive their infections, though they experienced significant complications. These cases highlight the importance of careful screening of organ donors for undetected infections.

Occurrence of Pathogenic and Allergenic Molds in the Outdoor and Indoor Environment of a Major Hospital and Molecular Epidemiology of Aspergillus fumigatus in Kuwait

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Researchers in Kuwait found many types of mold in and around a hospital, with some being resistant to common antifungal medications. They discovered that the same mold species were found both outdoors and in the hospital environment, suggesting patients could catch infections from the surrounding air. The study identified molds that could cause serious infections in vulnerable patients and found that about 10% of environmental samples contained drug-resistant strains that were also found in sick patients.

therapeutic action: Voriconazole