therapeutic action: symptom resolution

Schizophyllum commune infection following chimeric antigen receptor T-cell therapy in a patient with lymphoma

A 71-year-old woman receiving CAR T-cell therapy for lymphoma developed a rare fungal lung infection caused by Schizophyllum commune six months after treatment. The infection presented similarly to other fungal diseases affecting the lungs and was diagnosed through bronchoscopy and fungal culture despite negative blood antibody tests. Standard antifungal medication (voriconazole) taken by mouth for four months completely resolved the infection, highlighting the need to consider rare fungi in patients receiving advanced cancer immunotherapies.

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An Atypical Presentation of Allergic Bronchopulmonary Aspergillosis

A 57-year-old man without prior lung problems developed a persistent cough and breathing difficulties that didn’t respond to antibiotics. Imaging showed his lung had collapsed and fluid had accumulated around it, raising concerns about cancer. However, bronchoscopy revealed the collapse was caused by thick mucus plugs filled with Aspergillus fungus rather than cancer. After treatment with antifungal medication and steroids, the patient fully recovered with his lung re-expanding and fluid resolving.

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