therapeutic action: symptom remission

Psychedelics for the Treatment of Obsessive–Compulsive Disorder: Efficacy and Proposed Mechanisms

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Psilocybin mushrooms show promise as a treatment for obsessive-compulsive disorder (OCD), a condition where people experience unwanted intrusive thoughts and compulsive behaviors. Current standard treatments with antidepressants don’t work for many patients and take weeks to show effects. Early research suggests psilocybin may reduce OCD symptoms quickly and works in treatment-resistant cases, though more rigorous studies are needed to confirm its effectiveness and understand how it works in the brain.

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Identification of Blood Biomarkers of Psilocybin-Assisted Therapy Treatment Response for Generalised Anxiety Disorder

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Researchers studied how psilocybin-assisted therapy works for people with anxiety disorders by examining blood samples from patients who responded well to treatment versus those who didn’t. They identified four genes whose expression patterns could help predict which anxiety patients would benefit from psilocybin therapy before starting treatment. This breakthrough could help doctors avoid giving intensive treatment to patients unlikely to respond and instead direct them toward more effective alternatives.

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Efficacy of psilocybin for treating symptoms of depression: systematic review and meta-analysis

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This comprehensive analysis of clinical trials found that psilocybin, a compound found in certain mushrooms, shows promise as a treatment for depression compared to placebo. The treatment was particularly effective for patients with depression related to serious illness, those using self-reported symptom assessments, older adults, and those with prior experience with psychedelics. While side effects were minimal and temporary, researchers emphasize that more research is needed to fully understand how expectancy and individual factors influence treatment outcomes.

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