therapeutic action: Surgical intervention

Bridging gaps in the elimination of deep mycoses: a comparative analysis of mycetoma and chromoblastomycosis control strategies in Rwanda and China

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Mycetoma and chromoblastomycosis are serious fungal infections that primarily affect poor communities in tropical regions, causing permanent disability and limb loss. This review compares how China and Rwanda are tackling these diseases, finding that China has advanced laboratories and testing methods while Rwanda excels at reaching rural communities. The study recommends that both countries work together, combining China’s advanced diagnostic technology with Rwanda’s successful community health approach to better control these neglected diseases.

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Breakthrough Invasive Mould Infections Under Posaconazole Prophylaxis in Patients With Haematologic Malignancies: A Case–Control Study

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This study examined cases where patients receiving posaconazole to prevent fungal infections still developed serious mould infections despite the medication. Researchers compared 29 patients who developed these breakthrough infections with 46 control patients who did not. They found that over half of patients with breakthrough infections died, compared to only 20% of controls, and that surgical treatment significantly improved survival for certain types of fungal infections.

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A case of spontaneous abdominal hemoperitoneum secondary to ruptured splenosis

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This case report describes a rare complication where ectopic splenic tissue (splenosis) that had grown in the abdomen following a previous spleen removal suddenly ruptured and caused severe internal bleeding. The 35-year-old patient developed acute abdominal pain and underwent emergency surgery to remove the bleeding tissue and stop the hemorrhage. The surgery was successful and the patient recovered well, highlighting the importance of considering splenosis in the differential diagnosis of unexplained abdominal bleeding in patients with prior spleen removal.

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Catastrophic Cerebral Infarctions in a Pediatric Patient with Acute Lymphoblastic Leukemia Due to Mucorales Infection

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An 11-year-old girl with leukemia undergoing chemotherapy developed a severe fungal infection called mucormycosis caused by Lichtheimia ramosa. The infection spread rapidly from her sinuses to her eyes and brain, causing multiple blood clots in brain arteries and a massive stroke within just five days. Despite emergency surgery to remove the clots, the infection had progressed too far and the patient sadly did not survive, highlighting how dangerous this fungal infection can be in children with weakened immune systems.

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Consecutive non-Aspergillus Fungal Invasive Infections in Chronic Granulomatous Disease: Data from the French National Reference Center for Primary ImmunoDeficiencies and literature review

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This study examines rare fungal infections in patients with Chronic Granulomatous Disease, a genetic disorder affecting the immune system. Researchers found that these patients develop various unusual fungal infections despite taking preventive antifungal medications. The infections are difficult to diagnose, often requiring surgical procedures, but can sometimes be cured through stem cell transplantation combined with intensive antifungal treatment.

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Consecutive non-Aspergillus Fungal Invasive Infections in Chronic Granulomatous Disease: Data from the French National Reference Center for Primary ImmunoDeficiencies and literature review

mycolabadmin

This study examines rare but serious fungal infections in patients with chronic granulomatous disease, a genetic immune disorder. Researchers analyzed 122 cases of non-Aspergillus fungal infections from French hospitals and published literature, finding that these infections often occur despite preventive antifungal medications and are challenging to diagnose. The infections were found in the lungs most commonly but could spread to bones, brain, and other organs, with treatments including antifungal drugs, surgery, and in some cases bone marrow transplants.

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