Fusarium fungi cause serious diseases in crops like wheat, rice, and vegetables worldwide, leading to significant food losses and contamination with harmful toxins. Phenamacril is a modern fungicide designed to fight these fungi by targeting a specific protein called myosin-5. However, the fungi have developed resistance to this fungicide through genetic changes and other mechanisms, making it less effective over time. Farmers need to use multiple strategies including crop rotation and resistant plant varieties rather than relying only on fungicides to successfully manage these diseases.