A 22-year-old man suffered severe injuries from a motorcycle-truck collision that damaged his perineal area and left thigh. Despite antibiotics and wound therapy, a dangerous fungal infection called mucormycosis developed in the wound. The medical team treated this by repeatedly removing infected tissue, using powerful antifungal medications (amphotericin B and posaconazole), and carefully managing the wound with special therapy before skin grafting, ultimately achieving successful healing.