therapeutic action: Serotonin receptor agonism

Exploring the neurobiological correlates of psilocybin-assisted psychotherapy in eating disorders: a review of potential methodologies and implications for the psychedelic study design

This review examines how psilocybin-assisted therapy might work for eating disorders by looking at various ways to measure changes in the brain. The authors discuss different brain imaging techniques and other tools that scientists could use to understand how psilocybin affects the brains of people with eating disorders. They emphasize that combining multiple measurement approaches provides the best understanding of how this emerging treatment works and can guide future research and clinical applications.

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Horizontal gene cluster transfer increased hallucinogenic mushroom diversity

Scientists discovered that distantly related hallucinogenic mushrooms produce psilocybin, the psychoactive compound in magic mushrooms, through a shared set of genes that were likely transferred between species living in similar environments like dung and decaying wood. By sequencing the genomes of three different hallucinogenic mushroom species, researchers found nearly identical gene clusters responsible for making psilocybin, and evidence showing these genes jumped between unrelated fungal lineages. This discovery suggests that fungi in dung and wood environments may be rich sources of other bioactive compounds with potential medical applications.

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