ROS scavenging – mycolab.ai

A Review of Novel Antioxidant Ergothioneine: Biosynthesis Pathways, Production, Function and Food Applications

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Ergothioneine is a powerful natural antioxidant found mainly in mushrooms that protects cells from damage and may help prevent diseases like Alzheimer’s and heart disease. Currently, producing ergothioneine from mushrooms is expensive and slow, but scientists have developed faster fermentation methods using engineered microbes that could make it cheaper and more available. This compound can be added to foods and supplements to boost health benefits, and researchers are exploring its use beyond seafood to other food products like meat and baked goods.

Biological Characteristics, Domesticated Cultivation Protocol, Antioxidant Activity, and Protective Effects against Cellular Oxidative Stress of an Underutilized Medicinal Mushroom: Fomitopsis palustris

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Researchers successfully grew and studied Fomitopsis palustris, a medicinal mushroom, in laboratory conditions. They discovered that the mushroom contains beneficial compounds that protect cells from damage caused by harmful free radicals. The polysaccharides extracted from the mushroom boosted the cells’ natural defense systems and reduced oxidative stress markers, suggesting potential health benefits for treating age-related and degenerative diseases.

Analysis of Volatile Organic Compounds and Comparison of Heat Resistance Related Gene Expression in Pleurotus ostreatus Under Heat Stress

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This study examined how oyster mushrooms respond to high temperatures at different growth stages. Researchers found that young mycelium and mature fruiting bodies use different strategies to survive heat stress, which affects the flavor compounds they produce. Mycelium produces more of certain volatile compounds under heat stress, while fruiting bodies actually lose their characteristic mushroom flavor compound called 1-Octen-3-ol.

Neuroprotective Effect of Mixed Mushroom Mycelia Extract on Neurotoxicity and Neuroinflammation via Regulation of ROS-Induced Oxidative Stress in PC12 and BV2 Cells

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A mixture of three medicinal mushrooms (Phellinus linteus, Ganoderma lucidum, and Inonotus obliquus) was tested for its ability to protect nerve cells from damage. The extract successfully reduced cell death in laboratory models of neurodegeneration by reducing harmful molecules called reactive oxygen species and reducing inflammation. These results suggest the mushroom extract could potentially help prevent or slow neurological diseases like Alzheimer’s.

Exogenous MnSO4 Improves Productivity of Degenerated Volvariella volvacea by Regulating Antioxidant Activity

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This study shows that adding manganese sulfate to degenerated mushroom strains can restore their ability to grow and produce fruit bodies. The treatment works by improving the mushrooms’ natural defense systems against damaging free radicals and enhancing enzymes that break down the growing medium. Results showed significantly improved growth rates, shorter production times, and even allowed severely damaged strains to produce mushrooms again.

Ergothioneine: An Antioxidative, Neuroprotective and Anti-Inflammatory Compound from Mushroom Residuals

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Ergothioneine is a powerful antioxidant found mainly in mushrooms that protects brain health and reduces inflammation. Mushroom processing creates large amounts of waste like stems and leftover substrate that actually contain high levels of this beneficial compound. Scientists have developed sustainable methods to extract ergothioneine from this waste, creating opportunities for new health supplements and functional foods while reducing waste and supporting environmental sustainability.

Plant and Fungal Polysaccharides in Periodontitis Treatment: Diverse Mechanisms and Therapeutic Roles

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Periodontitis is a serious gum disease that causes tooth loss and affects overall health. This review examines how polysaccharides (complex carbohydrates) from plants and fungi can help treat periodontitis by reducing inflammation, fighting bacteria, and helping gum tissue repair. These natural compounds work through multiple biological pathways to improve oral health outcomes while avoiding the side effects and resistance problems associated with conventional drugs.

Flammulina velutipes polysaccharides exhibit potent antioxidant and anti-pyroptotic properties in diabetes-associated periodontitis: A preliminary in vitro study

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Researchers studied a compound from the Flammulina velutipes mushroom (enoki mushroom) to see if it could help protect gum tissue in people with both diabetes and gum disease. Using human gum cell samples exposed to disease-simulating conditions, they found that the mushroom polysaccharides reduced cell damage, decreased inflammation, and prevented a harmful type of cell death called pyroptosis. The results suggest this mushroom compound could potentially be used as a supplementary treatment for people with diabetes-related gum disease.

Integrated Transcriptomics and Metabolomics Provide Insight into Degeneration-Related Molecular Mechanisms of Morchella importuna During Repeated Subculturing

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Morel mushrooms lose quality when repeatedly cultured in laboratories, becoming slower-growing and less vibrant. Scientists discovered this happens because genes controlling antioxidant production shut down, allowing harmful free radicals to damage cells. By avoiding frequent subculturing and using cold storage or antioxidant supplements, farmers can keep their morel strains healthy and productive for longer.

Diet-Derived Advanced Glycation End-Products (AGEs) Induce Muscle Wasting In Vitro, and a Standardized Vaccinium macrocarpon Extract Restrains AGE Formation and AGE-Dependent C2C12 Myotube Atrophy

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This research shows that processed foods high in sugar and fat create harmful compounds called AGEs that can cause muscle loss and weakness. Cranberry extract, which contains natural antioxidants, was found to be particularly effective at blocking AGE formation and preventing muscle cell damage. The study suggests that eating foods containing cranberry extract might help prevent age-related muscle loss and the negative effects of unhealthy Western diets on muscle health.

therapeutic action: ROS scavenging