therapeutic action: ROS generation

Recent innovations and challenges in the treatment of fungal infections

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Fungal infections are becoming more common and dangerous, especially for people with weakened immune systems, and many fungi are developing resistance to current medications. Doctors and researchers are developing new treatment strategies, including combining multiple drugs together and using advanced technologies to deliver medicines more effectively to infected areas. Natural compounds from plants and new biotechnology tools like genetic engineering and nanoparticles show promising results for fighting drug-resistant fungal infections.

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Synthesis of zinc oxide nanoparticles using Trichoderma harzianum and its bio-efficacy on Alternaria brassicae

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Scientists have developed an eco-friendly way to create zinc oxide nanoparticles using a beneficial fungus called Trichoderma harzianum. These nanoparticles effectively kill Alternaria brassicae, a fungus that damages mustard crops and can reduce yields by up to 57%. The nanoparticles work better and at lower doses than traditional chemical fungicides, making them a promising sustainable solution for farmers. This represents an important advancement in protecting crops without harming the environment.

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Potential of Indonesian Herbal as an Anti-Cancer Therapy: A Systemic Review of in vitro Studies

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This review examined eight Indonesian herbal plants that show promise in laboratory studies for fighting various types of cancer. Soursop leaves were the most researched and consistently showed the ability to kill or slow cancer cells in test tubes by triggering natural cell death pathways. The herbs work through bioactive compounds like flavonoids and alkaloids that can interfere with how cancer cells divide and survive. While these results are encouraging, more research is needed to confirm effectiveness in humans.

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Graphene nanomaterials: A new frontier in preventing respiratory fungal infections

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Graphene nanomaterials, especially nano-graphene oxide, show promise as new treatments for serious lung fungal infections that particularly threaten people with weakened immune systems. These tiny materials work by generating damaging reactive oxygen species that kill fungal cells and prevent biofilm formation. Unlike traditional antifungal drugs, nano-graphene oxide can be delivered directly to infected lung tissue via inhalation, delivering medicine exactly where needed while reducing harmful side effects throughout the body.

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Caged-hypocrellin mediated photodynamic therapy induces chromatin remodeling and disrupts mitochondrial energy metabolism in multidrug-resistant Candida auris

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Researchers developed a new photodynamic therapy treatment using a light-activated compound called COP1T-HA to fight drug-resistant Candida auris infections. The therapy works by reorganizing the fungal cell’s genetic material architecture and disrupting energy production in mitochondria, ultimately killing the fungal cells. This approach represents a novel strategy to overcome antibiotic resistance, as it targets multiple cellular processes rather than a single pathway that fungi can easily resist.

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Improving treatment of chromoblastomycosis: the potential of COP1T-HA and antimicrobial photodynamic therapy against Fonsecaea monophora in vitro

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Chromoblastomycosis is a stubborn skin fungal infection that is difficult to treat with current medications and often comes back after treatment. Researchers tested a new treatment using a special light-activated compound called COP1T-HA combined with blue light, which successfully killed the fungus in laboratory tests. The treatment worked quickly and at low doses, showing promise as a potential new therapy for this challenging infection.

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Glucose-6-Phosphate Dehydrogenase Modulates Shiraia Hypocrellin A Biosynthesis Through ROS/NO Signaling in Response to Bamboo Polysaccharide Elicitation

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Researchers discovered that a specific enzyme called glucose-6-phosphate dehydrogenase (G6PDH) controls the production of hypocrellin A, a powerful therapeutic compound found in Shiraia fungi. When bamboo polysaccharides are added to fungal cultures, they trigger G6PDH activity, which then increases the production of signaling molecules that boost hypocrellin A biosynthesis. This finding could lead to better ways to produce this promising cancer-fighting photosensitizer at industrial scales using simple, cost-effective methods.

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