therapeutic action: ROS accumulation

Cinchona-based liquid formulation exhibits antifungal activity through Tryptophan starvation and disruption of mitochondrial respiration in Rhizoctonia Solani

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Researchers found that an extract from Cinchona bark, containing the compound quinine, effectively kills rice-damaging fungus Rhizoctonia solani through two mechanisms: starving the fungus of the amino acid tryptophan and disrupting its energy-producing mitochondria. This natural plant-based treatment could serve as an eco-friendly alternative to synthetic fungicides, reducing crop losses from fungal diseases while avoiding the environmental damage and resistance problems associated with chemical pesticides.

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Terpinen-4-ol triggers autophagy activation and metacaspase-dependent apoptosis against Botrytis cinerea

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Terpinen-4-ol, a natural compound from tea tree oil, effectively kills gray mold fungus that spoils fruits and vegetables after harvest. The compound works by damaging fungal cell membranes, creating harmful reactive molecules inside fungal cells, and triggering the fungal cells’ self-destruction pathways. When tested on tomatoes and strawberries, terpinen-4-ol successfully reduced mold growth and disease spread, suggesting it could be a safe, eco-friendly alternative to chemical fungicides for protecting fresh produce.

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