therapeutic action: reactive oxygen species scavenging

Exploring Psilocybe spp. mycelium and fruiting body chemistry for potential therapeutic compounds

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This study compared the chemical makeup of psilocybin mushroom mycelium (the root-like growth) versus fruiting bodies (the mushrooms themselves) to understand their different therapeutic potential. While fruiting bodies contain much higher levels of psilocybin, the psychoactive compound, mycelium accumulates other beneficial compounds like α-GPC that may enhance cognition and motor function without strong psychedelic effects. This research suggests that mushroom mycelium could be developed as a non-intoxicating therapeutic alternative with its own unique health benefits.

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Anti-Xanthine Oxidase 5′-Hydroxyhericenes A–D from the Edible Mushroom Hericium erinaceus and Structure Revision of 3-[2,3-Dihydroxy-4-(hydroxymethyl)tetrahydrofuran-1-yl]-pyridine-4,5-diol

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Researchers isolated new compounds from Lion’s mane mushroom (Hericium erinaceus) that can inhibit xanthine oxidase, an enzyme linked to breast cancer development. One compound called hericerin showed strong activity against a specific type of breast cancer cell (T47D cells) while being less harmful to normal cells. The study also corrected a misidentification from previous research, confirming that a compound previously thought to have a different structure was actually adenosine. These findings suggest Lion’s mane could be developed into a natural anti-cancer treatment.

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Integrated transcriptome and metabolome profiling reveals mechanisms underlying the infection of Cytospora mali in “Jin Hong” branches

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This research examined how apple trees defend themselves against a serious fungal disease called Valsa canker caused by Cytospora mali. Scientists used advanced genetic and chemical analysis techniques to identify which genes and protective compounds are activated when apple branches are infected. They found that healthy apple trees fight the infection by strengthening their cell walls, producing special protective enzymes, and accumulating defense chemicals like α-linolenic acid and betaine. These discoveries could help develop better ways to prevent or manage this destructive disease in apple orchards.

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