therapeutic action: Rapid onset of action

The Role of Psychedelics in the Treatment of Substance Use Disorders: An Overview of Systematic Reviews

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This research review examines how psychedelic drugs like psilocybin and ketamine might help treat addiction. Studies show these substances could help people quit alcohol, drugs, and smoking by reducing cravings and promoting long-term abstinence. While results are promising, scientists caution that more rigorous research is needed before these treatments can be recommended for regular medical use, and they acknowledge real risks associated with these powerful drugs.

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Efficacy of psilocybin for treating symptoms of depression: systematic review and meta-analysis

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This comprehensive analysis of clinical trials found that psilocybin, a compound found in certain mushrooms, shows promise as a treatment for depression compared to placebo. The treatment was particularly effective for patients with depression related to serious illness, those using self-reported symptom assessments, older adults, and those with prior experience with psychedelics. While side effects were minimal and temporary, researchers emphasize that more research is needed to fully understand how expectancy and individual factors influence treatment outcomes.

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Psilocybin-assisted massed cognitive processing therapy for chronic posttraumatic stress disorder: Protocol for an open-label pilot feasibility trial

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This study tests whether psilocybin (a psychedelic compound) combined with intensive therapy can help treat chronic PTSD better than therapy alone. Fifteen patients with PTSD will receive one dose of psilocybin alongside 12 therapy sessions completed over a single week. Researchers will track feasibility, safety, symptom improvements, and use wearable devices to monitor physiological changes. The results will help determine whether larger trials should test this innovative combination therapy.

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