A 46-year-old man developed a severe fungal infection caused by a rare fungus called Basidiobolus ranarum in his thigh, which started from an insect bite two years earlier. The infection caused tissue death and was complicated by bacterial superinfection, requiring aggressive treatment with multiple antibiotics and antifungal medications along with several surgeries. Doctors used a combination approach including voriconazole, potassium iodide, and itraconazole to finally control the infection, though amputation was necessary due to the extent of tissue damage. The case highlights the importance of early medical care and demonstrates that rare fungal infections can be life-threatening even in otherwise healthy people.