therapeutic action: pollutant remediation

Computer-directed rational engineering of dioxygenase TcsAB for triclosan biodegradation under cold conditions

Scientists engineered a special enzyme called TcsAB to work better at cold temperatures, enabling it to break down triclosan, a harmful antibacterial chemical that pollutes our water. By using computer simulations and strategic mutations, they created a modified enzyme that degrades triclosan 2.5 times more efficiently at 15°C. When inserted into bacteria, this engineered enzyme helps clean up triclosan pollution in natural environments without requiring energy-intensive heating.

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Degradation of High Concentrations of Anthracene Using White-Rot Wood-Inhabiting Fungi and Investigation of Enzyme Activities

Scientists in Iran discovered that certain wood-decay fungi, particularly Trametes versicolor mushrooms, can effectively break down anthracene, a toxic pollutant from oil and gas industries. These fungi produce special enzymes that degrade the harmful chemical into less toxic substances. In laboratory tests, these indigenous Iranian fungi successfully removed 20-64% of high-concentration anthracene over four weeks, showing promise for cleaning up contaminated sites.

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