therapeutic action: oxidative stress resistance

Integration of Physiological, Transcriptomic and Metabolomic Reveals Molecular Mechanism of Paraisaria dubia Response to Zn2+ Stress

This research shows that a fungus called Paraisaria dubia can effectively clean up zinc pollution by removing 60% of zinc from contaminated environments. The fungus uses multiple survival strategies when exposed to zinc stress, including producing more protective slime-like substances on its surface and generating spores that are more resistant to harmful conditions. By studying the fungus at the molecular level, scientists discovered which genes and chemical compounds activate these protective responses, paving the way for using fungi as natural cleaners for heavy metal-contaminated soil and water.

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A Zn2-Cys6 transcription factor, TgZct4, reprograms antioxidant activity in the fungus Trichoderma guizhouense to defend against oxidative stress

A fungal biocontrol agent called Trichoderma guizhouense uses a special protein called TgZct4 to protect itself from harmful oxidative stress caused by hydrogen peroxide. When the fungus encounters this stress, TgZct4 activates a series of antioxidant enzymes that neutralize the damaging reactive oxygen species. This discovery helps explain how this beneficial fungus can survive and control plant diseases in harsh soil environments, potentially improving its use as an environmentally friendly alternative to chemical pesticides.

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