neuroprotective – mycolab.ai

Medicinal Mushrooms: Bioactive Compounds, Use, and Clinical Trials

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This comprehensive review examines how medicinal mushrooms contain natural compounds that can boost immune function, fight cancer cells, reduce inflammation, and protect nerve cells. Different mushroom species like reishi, shiitake, and maitake contain various active substances such as beta-glucans and triterpenes that work through multiple biological pathways. While laboratory and animal studies show promising results, more human clinical trials are needed to confirm effectiveness and establish safe dosing guidelines.

Transcriptome and Metabolome Reveal Accumulation of Key Metabolites with Medicinal Properties of Phylloporia pulla

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Scientists studied a medicinal fungus called Phylloporia pulla to understand which health-promoting compounds it produces and how it makes them. Using advanced genetic and chemical analysis tools, they discovered the fungus produces beneficial compounds like steroids and triterpenoids that have anti-inflammatory and anti-cancer properties, with production peaking around the middle of the fungus’s growth cycle. They identified six key genes that control the production of celastrol, a particularly valuable compound with potential to treat diseases like Alzheimer’s and cancer. This research helps explain why this fungus has been used traditionally in medicine and provides guidance for growing it to maximize production of these beneficial compounds.

Special Issue: Marine-Derived Compounds Applied in Cardiovascular Disease

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This collection of studies explores how compounds from ocean sources like seaweed, fish, shrimp, and microalgae can help protect heart health and prevent cardiovascular diseases. Researchers examined various marine ingredients and found they can reduce inflammation, lower cholesterol, reduce blood pressure, and prevent blood clots. The findings suggest that marine-derived products could become safer, more affordable alternatives or complements to current heart disease medications while supporting sustainable ocean resource use.

Molecular docking as a tool for the discovery of molecular targets of nutraceuticals in diseases management

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This review explains how scientists use computer simulations to understand how natural food compounds (called nutraceuticals) interact with disease-causing molecules in the body. By using molecular docking software, researchers can predict which compounds might fight diseases like cancer and heart disease before conducting expensive laboratory tests. The review shows that many common foods like turmeric, grapes, and green tea contain compounds that could potentially treat various diseases by targeting specific proteins and pathways involved in disease development.

A putative ABC transporter gene, CcT1, is involved in beauvericin synthesis, conidiation, and oxidative stress resistance in Cordyceps chanhua

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Cordyceps chanhua is a medicinal fungus used in traditional Chinese medicine that produces a compound called beauvericin, which has health benefits but can be toxic in high amounts. Researchers discovered a gene called CcT1 that controls how much beauvericin the fungus makes. By removing this gene, they could reduce beauvericin production by 64%, making the fungus safer to use as medicine while maintaining other beneficial properties.

Therapeutic and Nutraceutical Potential of Sargassum Species: A Narrative Review

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Sargassum is a type of ocean seaweed that has been used in traditional medicine for centuries and contains compounds that may help fight inflammation, oxidative stress, viruses, and bacteria. Scientists have discovered that different Sargassum species produce nearly 200 different bioactive compounds with potential health benefits ranging from reducing arthritis symptoms to supporting immune function. While Sargassum can accumulate harmful heavy metals like arsenic from seawater, researchers have developed effective cleaning methods to remove these contaminants while preserving the beneficial compounds. This makes Sargassum a promising sustainable source of natural medicines and health supplements.

Solid-state fermentation as a strategy for improvement of bioactive properties of the plant-based food resources

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This review explains how fermentation—a natural biological process—can enhance the health-promoting compounds in plant-based foods. By using specific fungi and bacteria on solid plant materials, scientists can increase beneficial antioxidants and proteins that may help prevent chronic diseases. This method is more environmentally friendly and cost-effective than traditional extraction techniques, making nutritious plant foods even healthier.

In vitro assessment of multipotential therapeutic importance of Hericium erinaceus mushroom extracts using different solvents

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This research examined how Lion’s Mane mushroom extracts made with different liquids can fight infections and oxidative damage. The water-based extract was best at preventing viruses and free radical damage, while the ethyl acetate extract worked best against bacteria and fungi. The study identified 16 beneficial compounds in the mushroom and suggests it could be used as a daily supplement to protect against infections and oxidative stress.

Olive mill solid waste induces beneficial mushroom-specialized metabolite diversity revealed by computational metabolomics strategies

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This study shows how adding olive mill waste to mushroom growing substrate can increase beneficial compounds in mushrooms while reducing harmful toxins. Researchers grew two types of edible mushrooms (lion’s mane and king oyster) on substrate containing different amounts of olive mill waste and used advanced chemical analysis to identify how the waste affected the mushrooms’ medicinal compounds. Adding olive mill waste increased healthy compounds like hericenones and erinacerins while decreasing toxic enniatin compounds, potentially creating safer and more nutritious mushrooms for consumers.

A multilocus phylogeny of Hericium (Hericiaceae, Russulales)

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Researchers conducted the first comprehensive genetic study of lion’s mane mushrooms (Hericium species) using advanced DNA sequencing techniques. The study resolved long-standing confusion about different species and their relationships, while also describing a new species from western North America. These mushrooms are prized both as food and for traditional medicinal uses, particularly in Asia, and contain compounds with potential anti-inflammatory, antimicrobial, and neuroprotective properties. Better identification of species will help both commercial cultivators and medical researchers work with the correct organisms.

therapeutic action: neuroprotective