therapeutic action: neuritogenesis

The collective lie in ketamine therapy: a call to realign clinical practice with neurobiology

This article argues that ketamine therapy is commonly misunderstood as a consciousness-expanding psychedelic when it actually works through a completely different biological mechanism. The real therapeutic benefit comes from the brain’s natural reorganization in the days after treatment, not from the altered states people experience during the session itself. The authors call for medical practitioners to stop emphasizing the dissociative experience and instead focus on helping patients build healthy thought patterns during the recovery period when the brain is most ready to form new connections.

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Psychedelics action and schizophrenia

This review examines how psychedelic drugs like psilocybin and LSD affect the brain, particularly through serotonin receptors. While these compounds can produce psychosis-like symptoms similar to schizophrenia, they also promote brain plasticity and growth of neural connections. The article discusses whether psychedelics could potentially treat negative symptoms and cognitive problems in schizophrenia patients, despite their mind-altering properties, possibly through lower doses or non-hallucinogenic alternatives.

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Influences of substrate and tissue type on erinacine production and biosynthetic gene expression in Hericium erinaceus

This study examined how different growing conditions and tissue types affect erinacine production in lion’s mane mushrooms. Researchers found that mycelium (the fungal threads) produced far more erinacines than fruit bodies, and that the type of growth medium significantly influenced which erinacines were produced. Interestingly, changes in erinacine production weren’t always reflected in gene activity levels, suggesting other cellular mechanisms control these beneficial compounds.

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Influences of substrate and tissue type on erinacine production and biosynthetic gene expression in Hericium erinaceus

Researchers studied how different growing conditions affect erinacine production in lion’s mane mushroom mycelium. They found that the type of nutrients provided (substrate) significantly influences which erinacines are produced, even when the genes responsible for making these compounds show similar activity levels. Mycelium produced much more erinacines than fruit bodies, and specific nutrients could be used to encourage production of specific beneficial compounds.

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