therapeutic action: modulation of innate immune responses

PTP1B deficiency in myeloid cells increases susceptibility to Candida albicans systemic infection by modulating antifungal immunity

This research shows that a protein called PTP1B plays an important role in protecting the body against dangerous fungal infections caused by Candida albicans. When mice lacked this protein in their immune cells, they were much more susceptible to the infection and showed severe illness. The study found that PTP1B helps immune cells like macrophages and neutrophils fight the fungus effectively, and blocking this protein could actually make fungal infections worse.

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