Micafungin – Page 2

Spectrum of Fungal Infections in Continuous Ambulatory Peritoneal Dialysis: A 20-Year Retrospective Study From a Tertiary Care Center

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This study examined fungal infections in patients undergoing continuous ambulatory peritoneal dialysis (CAPD) over 20 years at a major Indian hospital. Researchers identified various fungal species causing peritonitis, with Candida species being most common, but discovered increasingly rare fungi involved in these infections. The study found that proper identification of the specific fungus and testing for drug resistance is crucial for effective treatment, typically involving catheter removal and targeted antifungal medications.

COVID-19-associated Pulmonary Aspergillosis in Mechanically Ventilated Patients at 7 US Hospitals: Epidemiology and Estimated Likelihood of Invasive Pulmonary Aspergillosis—Results of the Prospective MSG-017 Study

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A fungal infection caused by Aspergillus commonly occurs in COVID-19 patients on ventilators, affecting about 7% of cases. The study found that having this infection was linked to high death rates, but it was unclear whether the fungal infection itself or the severe COVID-19 caused the deaths. Single positive test results for the fungus are not reliable for diagnosis, and antifungal drugs did not improve survival rates.

Candida krusei Empyema: A Lung Transplant Case and Systematic Review of the Literature

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Candida krusei is a dangerous yeast that causes a serious lung infection called empyema, where pus collects around the lungs. This infection is particularly difficult to treat because the yeast is resistant to common antifungal drugs like fluconazole and can form protective biofilms. This systematic review identified only ten cases of this rare infection in the medical literature, showing how uncommon but serious it is, and found that patients need aggressive treatment with multiple antifungal medications combined with surgical drainage to survive.

Epidemiology and outcomes of Candida-associated osteoarticular infections: A multicentre retrospective study from Turkey

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Researchers in Turkey studied 73 patients with rare bone and joint infections caused by Candida fungi over 10 years. They found that about half of the infections were caused by species other than the common C. albicans, with some showing resistance to fluconazole antibiotics. Surgical procedures to clean out infected tissue significantly improved patient recovery, while patients with diabetes had worse outcomes and recovered less completely.

Neonatal Invasive Candidiasis: Current Concepts

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Serious fungal infections (candidiasis) in newborns have become increasingly difficult to treat, especially in developing countries. The types of fungi causing these infections have changed dramatically, with many now resisting the standard fluconazole treatment. Modern medical care, like proper handwashing, environmental cleaning, and careful line care, is actually more effective at preventing these infections than giving preventive antifungal drugs. Healthcare providers need better tools for quickly identifying which fungal species is causing infection and which drugs will work against it.

Invasive Candidiasis in Contexts of Armed Conflict, High Violence, and Forced Displacement in Latin America and the Caribbean (2005–2025)

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This comprehensive review examines candida fungal infections in conflict-affected areas of Latin America and the Caribbean, where wars, violence, and displacement create dangerous conditions that make infections more likely and harder to treat. In these regions, mortality from candida bloodstream infections reaches 65% or higher among displaced populations, compared to about 45-60% in regular hospitals. The main problems are lack of proper diagnostic equipment, limited access to effective antifungal medications, malnutrition, overcrowding in shelters, and the emergence of drug-resistant fungal strains.

Invasive Cutaneous Mucormycosis in a Patient With Chronic Lymphocytic Leukemia on Obinutuzumab, Idelalisib, and Bruton Tyrosine Kinase Degrader: A Case Report

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A 74-year-old man with leukemia developed a serious fungal infection (mucormycosis) on his ankle while taking cancer-fighting drugs. The infection was diagnosed through tissue biopsy examination rather than standard culture tests. Treatment required both powerful antifungal medications and surgical removal of the infected leg below the knee. The patient recovered successfully after this aggressive treatment approach.

Occurrence of Pathogenic and Allergenic Molds in the Outdoor and Indoor Environment of a Major Hospital and Molecular Epidemiology of Aspergillus fumigatus in Kuwait

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Researchers in Kuwait found many types of mold in and around a hospital, with some being resistant to common antifungal medications. They discovered that the same mold species were found both outdoors and in the hospital environment, suggesting patients could catch infections from the surrounding air. The study identified molds that could cause serious infections in vulnerable patients and found that about 10% of environmental samples contained drug-resistant strains that were also found in sick patients.

therapeutic action: Micafungin