therapeutic action: memory improvement

Quercetin hybrid-hydrogel microparticles modulate gut microbiota and improve memory in an antibiotic-induced dysbiosis rat model

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A natural quercetin supplement formulated with fenugreek fiber was tested on rats with antibiotic-damaged gut bacteria. The supplement successfully restored healthy gut bacteria diversity, reduced gut inflammation, and improved memory performance. These benefits likely work through the gut-brain connection, where healthy bacteria produce beneficial chemicals that support brain function and reduce inflammation.

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Construction of a genetic linkage map and detection of quantitative trait locus for the ergothioneine content in tamogitake mushroom (Pleurotus cornucopiae var. citrinopileatus)

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Researchers created the first genetic map of tamogitake mushrooms to identify genes controlling ergothioneine content. Ergothioneine is an antioxidant compound that provides health benefits like fighting inflammation and protecting brain health. They found one key genetic marker that reliably predicts which mushrooms will have high ergothioneine levels, enabling farmers to selectively breed mushrooms with enhanced health benefits.

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Reprogramming astrocytic NDRG2/NF-κB/C3 signaling restores the diabetes-associated cognitive dysfunction

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This study found that regular exercise helps protect the brain of diabetic people from cognitive decline by boosting a protein called NDRG2 in astrocytes (brain support cells). The research shows that NDRG2 works by blocking harmful immune responses that damage synapses (connections between brain cells). In diabetic mice, exercise improved memory and learning ability while increasing NDRG2 levels, while blocking this protein reversed these benefits.

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