Membrane disruption – Page 2

Antifungal Activity of Selected Naphthoquinones and Their Synergistic Combination with Amphotericin B Against Cryptococcus neoformans H99

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Researchers tested five compounds called naphthoquinones for their ability to fight a dangerous fungal infection called cryptococcosis. They found that one compound called 2-MNQ works especially well when combined with the standard antifungal drug amphotericin B, making the treatment more effective. This discovery could lead to better treatments for people with weakened immune systems who are vulnerable to this infection.

Clinical aspects and recent advances in fungal diseases impacting human health

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Fungal infections are becoming a major health threat, affecting over a billion people worldwide. The main problems are difficulty diagnosing these infections, increasing resistance to current medications, and limited treatment options. Doctors and the public need better awareness, and new antifungal drugs with different approaches are needed to effectively treat resistant infections.

Antifungal activity and mechanism of novel peptide Glycine max antimicrobial peptide (GmAMP) against fluconazole-resistant Candida tropicalis

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Scientists developed a new antimicrobial peptide called GmAMP that can effectively kill drug-resistant fungal infections caused by Candida tropicalis, a pathogen resistant to common antifungal medications. The peptide works by damaging the fungal cell membrane and is safe for human use. In laboratory tests using insect larvae, the peptide successfully treated infections and reduced the fungal burden, suggesting it could become a new treatment option for patients with resistant fungal infections.

Graphene nanomaterials: A new frontier in preventing respiratory fungal infections

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Graphene nanomaterials, especially nano-graphene oxide, show promise as new treatments for serious lung fungal infections that particularly threaten people with weakened immune systems. These tiny materials work by generating damaging reactive oxygen species that kill fungal cells and prevent biofilm formation. Unlike traditional antifungal drugs, nano-graphene oxide can be delivered directly to infected lung tissue via inhalation, delivering medicine exactly where needed while reducing harmful side effects throughout the body.

Mechanism Analysis of Amphotericin B Controlling Postharvest Gray Mold in Table Grapes

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This research shows that amphotericin B, a natural compound produced by bacteria, can effectively prevent gray mold from spoiling table grapes after harvest. The compound works by damaging the mold’s cell membranes and also activates the grapes’ own defense systems. At a treatment level of 200 mg/L, it completely prevented mold growth on grapes over a three-day storage period, offering a safer, more environmentally friendly alternative to synthetic fungicides.

Mechanism Analysis of Amphotericin B Controlling Postharvest Gray Mold in Table Grapes

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Researchers discovered that amphotericin B, a natural compound produced by soil bacteria, effectively prevents gray mold disease on table grapes. The compound works by directly damaging the fungus’s cell membranes and also boosts the grape’s own defense mechanisms. This natural solution could replace harmful synthetic fungicides while extending the shelf life of grapes during storage and transport.

Antifungal Activity of Selected Naphthoquinones and Their Synergistic Combination with Amphotericin B Against Cryptococcus neoformans H99

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Scientists tested five synthetic compounds called naphthoquinones to see if they could fight a serious fungal infection called cryptococcosis. They found that one compound called 2-MNQ worked well against the fungus and was even more effective when combined with a standard antifungal drug (amphotericin B). The combination was strong enough to potentially allow lower doses of the existing drug, which could reduce side effects while improving treatment outcomes.

Graphene nanomaterials: A new frontier in preventing respiratory fungal infections

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Scientists are exploring nano-graphene oxide, a microscopic material made from graphene, as a new treatment for serious lung fungal infections. These tiny particles can kill fungal cells through multiple mechanisms and deliver antifungal drugs directly to infection sites while reducing harmful side effects. Researchers found that graphene oxide can be combined with existing antifungal medications to make them work better and even help overcome drug-resistant fungal infections.

Identification of an antifungal lipopeptide from Bacillus amyloliquefaciens HAU3 inhibiting the growth of Fusarium graminearum using preparative chromatography and 2D-NMR

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Researchers identified a soil bacterium called Bacillus amyloliquefaciens HAU3 that naturally produces fengycin, a powerful antifungal compound. This compound can kill disease-causing fungi like Fusarium graminearum that contaminate animal feed and produce harmful toxins. The bacteria also breaks down dangerous toxins called zearalenone, making it a potential natural solution for protecting livestock feed from fungal contamination.

therapeutic action: Membrane disruption