Membrane disruption – mycolab.ai

Microplastics and antibiotic resistance genes as rising threats: Their interaction represents an urgent environmental concern

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Tiny plastic particles called microplastics are spreading through our environment and creating a dangerous partnership with antibiotic-resistant bacteria. When these plastics accumulate in soil, water, and even food, they carry bacteria with genes that resist antibiotics, making infections harder to treat. This combined threat to human health can spread through wind, water, and the food chain, requiring urgent action to reduce plastic pollution and antibiotic overuse.

Nanoemulsion formulation of lemongrass essential oil using Pseudomonas-derived rhamnolipids for targeted phytopathogen suppression

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This study developed a nano-sized formulation of lemongrass oil stabilized with naturally-derived rhamnolipid surfactant to fight plant fungal diseases. The formulation successfully inhibited the growth of three major plant pathogens and remained stable during storage. This bio-based approach offers farmers an environmentally-friendly alternative to synthetic chemical fungicides for protecting crops.

Clinical aspects and recent advances in fungal diseases impacting human health

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Fungal infections are increasingly common health threats affecting over a billion people worldwide, ranging from minor allergies to serious life-threatening infections. The biggest problems are that fungi are becoming resistant to current medications, diagnosis can be difficult and slow, and treatment options are limited. Recent developments include new antifungal drugs like ibrexafungerp and rezafungin that work differently from older medications, offering hope for treating resistant infections. Better awareness among doctors and patients, faster diagnostic methods, and responsible use of antifungals are essential to combat this growing public health challenge.

Essential Oils as an Antifungal Alternative for the Control of Various Species of Fungi Isolated from Musa paradisiaca: Part I

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Researchers tested six essential oils from common kitchen herbs to see if they could prevent banana spoilage caused by fungi. They found that cinnamon oil was especially effective, stopping fungal growth at relatively low concentrations. This research suggests that natural essential oils could replace harsh chemical fungicides in farming, making bananas safer for consumers and better for the environment.

Terpinen-4-ol triggers autophagy activation and metacaspase-dependent apoptosis against Botrytis cinerea

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Terpinen-4-ol, a natural compound from tea tree oil, effectively kills gray mold fungus that spoils fruits and vegetables after harvest. The compound works by damaging fungal cell membranes, creating harmful reactive molecules inside fungal cells, and triggering the fungal cells’ self-destruction pathways. When tested on tomatoes and strawberries, terpinen-4-ol successfully reduced mold growth and disease spread, suggesting it could be a safe, eco-friendly alternative to chemical fungicides for protecting fresh produce.

Cestrum tomentosum L.f. Extracts against Colletotrichum scovillei by Altering Cell Membrane Permeability and Inducing ROS Accumulation

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Researchers found that extracts from the Cestrum tomentosum plant effectively kill a fungus that causes anthracnose disease in chili peppers. The plant extract works by damaging the fungal cell membranes and causing harmful reactive oxygen species to accumulate inside fungal cells. This natural remedy showed strong protective and therapeutic effects when applied to chili pepper fruits, offering a safer alternative to synthetic chemical fungicides.

Essential Oils as an Antifungal Alternative to Control Several Species of Fungi Isolated from Musa paradisiaca: Part III

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Researchers tested six essential oils from common culinary herbs to control fungal diseases that damage bananas after harvest. Thyme, cinnamon, and oregano oils were most effective at preventing fungal growth at concentrations between 600-1000 parts per million. These natural oils could replace synthetic fungicides in banana storage facilities, providing a safer, more environmentally friendly approach to preserving fruit quality.

Recent innovations and challenges in the treatment of fungal infections

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Fungal infections are becoming more common and dangerous, especially for people with weakened immune systems, and many fungi are developing resistance to current medications. Doctors and researchers are developing new treatment strategies, including combining multiple drugs together and using advanced technologies to deliver medicines more effectively to infected areas. Natural compounds from plants and new biotechnology tools like genetic engineering and nanoparticles show promising results for fighting drug-resistant fungal infections.

In vitro antifungal activity of plant extracts against fungal pathogens of onion (Allium cepa L.) and red pepper (Capsicum annum L.) in selected districts of Western Hararghe, Ethiopia

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Onion and pepper farmers in Ethiopia lose significant crops to fungal diseases, and chemical fungicides are expensive and harmful. This study tested plant extracts from garlic, neem, and African wintersweet against disease-causing fungi. Acokanthera schimperi (African wintersweet) was most effective at stopping fungal growth, offering farmers an affordable, natural, and environmentally safe alternative to chemical fungicides.

Graphene nanomaterials: A new frontier in preventing respiratory fungal infections

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Fungal lung infections are a serious problem, especially for people with weak immune systems. Researchers are exploring graphene nanomaterials as a new treatment approach that can deliver antifungal drugs directly to infected areas in the lungs. These tiny particles work by creating toxic stress inside fungal cells and breaking down their protective biofilms, while using smaller drug doses and causing fewer side effects than traditional treatments.

therapeutic action: Membrane disruption