therapeutic action: membrane damage

Inhibitory and synergistic effects of volatile organic compounds from bat caves against Pseudogymnoascus destructans in vitro

Researchers discovered that two natural compounds found in bat cave environments—isovaleric acid and ethyl methyl carbonate—can effectively kill the fungus that causes white-nose syndrome in bats. When used together, these compounds work even better than alone, disrupting the fungus’s cell membranes, causing it to produce too many reactive molecules (free radicals), and triggering cell death. This discovery offers hope for developing new treatments to protect bat populations that have been devastated by this disease in North America.

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Inhibitory Effects and Mechanisms of Perilla Essential Oil and Perillaldehyde against Chestnut Pathogen Botryosphaeria dothidea

Chestnut rot caused by the fungus Botryosphaeria dothidea is a major problem during fruit storage. Researchers found that essential oil from perilla plants and its main component perillaldehyde effectively kill this fungus by damaging its cell walls and membranes. This natural solution could replace harmful synthetic fungicides while keeping chestnuts fresh longer during storage.

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Comparative Study and Transcriptomic Analysis on the Antifungal Mechanism of Ag Nanoparticles and Nanowires Against Trichosporon asahii

Researchers compared two types of tiny silver particles (nanoparticles and nanowires) as potential treatments for a dangerous fungal infection caused by Trichosporon asahii. Silver nanowires were found to be more effective than nanoparticles at killing the fungus by damaging its cell membranes and disrupting its energy production. The study identified 15 key genes involved in how silver nanowires attack the fungus, suggesting these nanomaterials could become useful alternatives to traditional antifungal drugs.

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