therapeutic action: melanin inhibition

Synergistic impact of arbutin and kaempferol-7-O-α-l-rhamnopyranoside from Nephelium lappaceum L. on whitening efficacy and stability of cosmetic formulations

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This research demonstrates that a natural compound from rambutan seeds works synergistically with arbutin to create more effective skin whitening products. The combination is 35 times more potent than arbutin alone at preventing melanin production in skin cells. The resulting cosmetic formulation maintains its effectiveness and stability for approximately 5.2 months, offering a safer natural alternative to conventional skin lightening agents that can cause irritation.

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Mechanistic Insights into Tyrosinase-Catalyzed Metabolism of Hydroquinone: Implications for the Etiology of Exogenous Ochronosis and Cytotoxicity to Melanocytes

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Hydroquinone is a common ingredient in skin-lightening products that works through enzyme-mediated chemical reactions. This research revealed how an enzyme called tyrosinase processes hydroquinone through different chemical pathways, ultimately producing melanin-like compounds. The study found that long-term hydroquinone use may cause a darkening side effect called exogenous ochronosis through continued enzyme activity, and identified a new chemical marker to track this process.

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Safe and Effective Antioxidant: The Biological Mechanism and Potential Pathways of Ergothioneine in the Skin

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Ergothioneine is a natural compound found in certain fungi and bacteria that acts like a powerful antioxidant in the body. When applied to skin, it can protect against damage from sun exposure and environmental pollution, reduce signs of aging, and help calm inflammation. It’s particularly special because it automatically travels to damaged areas in the skin where it’s needed most, making it an efficient and targeted treatment ingredient for cosmetics.

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