liposomal amphotericin B – Page 2

Disseminated mucormycosis leading to a fatal gastrointestinal perforation in a pediatric case of EBV-associated Hemophagocytic lymphohistiocytosis

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A 12-month-old girl developed a serious immune system disorder called hemophagocytic lymphohistiocytosis triggered by Epstein-Barr virus infection. Despite aggressive treatment, she developed a life-threatening fungal infection caused by mucormycosis that spread throughout her digestive system. The case illustrates how fungal infections can rapidly progress and become fatal in children with severely weakened immune systems, emphasizing the need for doctors to recognize early warning signs like tissue darkening on the skin.

Consecutive non-Aspergillus Fungal Invasive Infections in Chronic Granulomatous Disease: Data from the French National Reference Center for Primary ImmunoDeficiencies and literature review

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This study examines rare fungal infections in patients with Chronic Granulomatous Disease, a genetic disorder affecting the immune system. Researchers found that these patients develop various unusual fungal infections despite taking preventive antifungal medications. The infections are difficult to diagnose, often requiring surgical procedures, but can sometimes be cured through stem cell transplantation combined with intensive antifungal treatment.

Epidemiology of mucormycosis in COVID-19 patients in northwest Iran: Rhizopus arrhizus as the predominant species

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During the COVID-19 pandemic, some patients developed a severe fungal infection called mucormycosis alongside their coronavirus infection. This study found that 63 COVID-19 patients in Iran developed mucormycosis, which primarily affected the sinuses and brain. The researchers identified that a fungus called Rhizopus arrhizus caused most infections, and patients who received corticosteroids (used to treat severe COVID-19) had a higher risk, especially those who developed diabetes from the steroids.

Co-Infection of Pulmonary Aspergillosis and Cryptococcal Meningitis in an HIV-Positive Patient: A Case Report

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This case describes a man with undiagnosed HIV who developed two serious fungal infections at the same time: a lung infection caused by Aspergillus fungus and a brain infection caused by Cryptococcus fungus. His extremely low immune system (CD4 count of 41) made him vulnerable to multiple opportunistic infections. Despite treatment with antifungal medications, his condition worsened and he passed away, highlighting the dangers of late HIV diagnosis.

Consecutive non-Aspergillus Fungal Invasive Infections in Chronic Granulomatous Disease: Data from the French National Reference Center for Primary ImmunoDeficiencies and literature review

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This study examines rare but serious fungal infections in patients with chronic granulomatous disease, a genetic immune disorder. Researchers analyzed 122 cases of non-Aspergillus fungal infections from French hospitals and published literature, finding that these infections often occur despite preventive antifungal medications and are challenging to diagnose. The infections were found in the lungs most commonly but could spread to bones, brain, and other organs, with treatments including antifungal drugs, surgery, and in some cases bone marrow transplants.

Invasive Rhinocerebral Mucormycosis Is a Rare Complication in Systemic Juvenile Idiopathic Arthritis Patient

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A 5-year-old girl with a serious joint disease called systemic juvenile idiopathic arthritis developed a dangerous fungal infection in her nasal cavity and brain area. The fungal infection, caused by a mold organism called Lichtheimia, occurred because her immune system was severely weakened by medications used to treat her arthritis. Doctors treated the infection with antifungal drugs and surgery, and the patient eventually recovered by switching to a different arthritis medication. This case highlights how the strong medications needed to control some childhood arthritis can unexpectedly cause serious fungal infections.

Epidemiology and outcomes of Candida-associated osteoarticular infections: A multicentre retrospective study from Turkey

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Researchers in Turkey studied 73 patients with rare bone and joint infections caused by Candida fungi over 10 years. They found that about half of the infections were caused by species other than the common C. albicans, with some showing resistance to fluconazole antibiotics. Surgical procedures to clean out infected tissue significantly improved patient recovery, while patients with diabetes had worse outcomes and recovered less completely.

Neonatal Invasive Candidiasis: Current Concepts

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Serious fungal infections (candidiasis) in newborns have become increasingly difficult to treat, especially in developing countries. The types of fungi causing these infections have changed dramatically, with many now resisting the standard fluconazole treatment. Modern medical care, like proper handwashing, environmental cleaning, and careful line care, is actually more effective at preventing these infections than giving preventive antifungal drugs. Healthcare providers need better tools for quickly identifying which fungal species is causing infection and which drugs will work against it.

Geotrichosis Due to Magnusiomyces capitatus: A Severe Emerging Invasive Fungal Disease

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A 71-year-old cancer patient receiving chemotherapy developed a severe blood infection caused by a rare fungus called Magnusiomyces capitatus. This emerging fungal infection caused septic shock and multiple organ failure despite treatment with antifungal medications. The case highlights how these rare fungi can be deadly in patients with weakened immune systems and emphasizes the importance of quick, accurate identification using advanced laboratory techniques to guide treatment decisions.

The tell-tale hearts: Donor-derived invasive fungal infections among orthotopic heart transplant recipients

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This case report describes two rare instances where fungal infections were transmitted from organ donors to heart transplant recipients. One involved a Candida infection and the other involved Aspergillus fungus, both causing serious bloodstream and heart infections. The patients required extensive antifungal medications and multiple surgeries to survive their infections, though they experienced significant complications. These cases highlight the importance of careful screening of organ donors for undetected infections.

therapeutic action: liposomal amphotericin B