Itraconazole treatment

Primary cutaneous mixed infection with Cryptococcus uniguttulatus and Mycobacterium tuberculosis

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A 43-year-old man had persistent facial skin lesions for seven years that initially appeared to be fungal infection caused by Cryptococcus uniguttulatus. Standard antifungal treatments failed to completely cure the condition. Advanced genetic testing revealed the lesions were actually caused by two simultaneous infections: the fungus and tuberculosis bacteria. Once both infections were properly identified and treated with appropriate medications, the skin lesions finally healed.

Spread of Antifungal-Resistant Trichophyton indotineae, United Kingdom, 2017–2024

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A fungal infection called Trichophyton indotineae, which originated in Asia, is rapidly spreading throughout the United Kingdom and becoming resistant to common antifungal treatments. The infection typically starts in the groin area and can spread to other parts of the body, and many cases fail to respond to standard antifungal drugs like terbinafine. Researchers tracked 157 cases over seven years and found the fungus now accounts for over a third of all dermatophyte infections sent to the UK reference laboratory. Doctors and laboratory professionals are being urged to recognize this emerging threat and consider better diagnostic and treatment strategies.

Phaeoacremonium tuscanicum and Phaeoacremonium indicum sp. nov. associated with subcutaneous phaeohyphomycosis

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Researchers identified and described two rare fungal infections caused by Phaeoacremonium species in human patients. One case involved a previously unknown fungal species in humans called Phaeoacremonium indicum, discovered in an Indian transplant patient with a knee infection. Both cases were successfully treated with surgery, with one patient also receiving antifungal medication, demonstrating effective treatment approaches for these unusual infections.

Spread of Antifungal-Resistant Trichophyton indotineae, United Kingdom, 2017–2024

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A dangerous fungal infection called Trichophyton indotineae is rapidly spreading across the United Kingdom, particularly among people with connections to South Asia. This infection causes stubborn skin rashes that don’t respond well to common antifungal treatments like terbinafine. The number of cases has skyrocketed, making up 38% of all dermatophyte infections by 2024, and doctors need to be aware of this emerging threat.

Sporothrix davidellisii: A new pathogenic species belonging to the Sporothrix pallida complex

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Scientists have identified a new fungal species called Sporothrix davidellisii that causes an infection in cats. This fungus was found in an infected cat in Australia and is related to other fungi that cause sporotrichosis, a skin disease in humans and animals. The discovery shows that cats can help scientists identify new fungal pathogens in their environments, making them important sentinels for tracking emerging diseases.

Photo Quiz: Asteroid bodies in a skin biopsy of a farmer

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A farmer developed a chain of red nodules on his arm after a wrist injury, which was diagnosed as sporotrichosis, a fungal infection caused by Sporothrix globosa. The diagnosis was confirmed through tissue biopsy, which showed distinctive asteroid bodies – yeast cells surrounded by radiating material that represents the body’s immune response. The infection was successfully treated with oral potassium iodide over 6 months, resulting in complete healing.

The frequency distribution of Aspergillus section Nigri from clinical and environmental samples in Iran

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Researchers studied black mold species (Aspergillus section Nigri) found in hospitals and the environment across Iran. They identified eight different species and found that certain types like A. welwitschiae were more common in ear infections while A. tubingensis was more prevalent in soil and air. These findings are important because some of these molds cause serious infections in humans and understanding where they live helps doctors predict and treat infections.

Phaeoacremonium tuscanicum and Phaeoacremonium indicum sp. nov. associated with subcutaneous phaeohyphomycosis

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Researchers identified two cases of rare fungal skin infections caused by Phaeoacremonium species. One case involved a new fungal species named Phaeoacremonium indicum discovered in an Indian patient, while the second case from Australia represented the first documented human infection with P. tuscanicum. Both patients were successfully treated through surgical removal of the infected tissue, though one patient was immunocompromised from a kidney transplant. This study highlights how genetic testing helps identify rare fungal species that cause human infections.

Phaeohyphomycosis due to Nigrograna chromolaenae in a cardiac transplant patient

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A 71-year-old heart transplant patient developed a slowly growing bump on his finger caused by a rare fungus called Nigrograna chromolaenae. Doctors initially tried common antifungal medications that didn’t work well, but the patient improved significantly when switched to posaconazole treatment. This is the first documented case of this particular fungus infecting a human, highlighting the importance of accurately identifying fungi to choose the right treatment.

Deep cutaneous phaeohyphomycosis caused by Cladophialophora boppii: A case report

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A 69-year-old woman with breast cancer developed a skin infection caused by a rare fungus called Cladophialophora boppii while taking dexamethasone for cancer treatment. Doctors diagnosed the infection through skin biopsy and fungal testing, then removed the infected area surgically. After three weeks of antifungal medication (itraconazole), the infection cleared completely and did not return during four months of follow-up. This case suggests that surgery combined with short-term antifungal treatment may be sufficient for this type of infection.

therapeutic action: Itraconazole treatment