Inhibition of mycelial growth

Baicalein as a potent antifungal agent against Candida albicans: synergy with fluconazole and sustainable production through probiotic-mediated bioconversion

mycolabadmin

Baicalein, a natural compound from a traditional medicinal plant, is significantly more effective at fighting Candida albicans infections than its parent compound baicalin. When combined with the common antifungal drug fluconazole, baicalein creates a powerful synergistic effect that is especially useful against drug-resistant fungal strains. Scientists discovered that a beneficial probiotic bacterium, Lactobacillus rhamnosus, can efficiently convert the abundant baicalin into baicalein, providing a sustainable and safe way to produce this potent antifungal compound at scale.

Synergistic inhibition of Aspergillus flavus by organic acid salts: growth, oxidative stress, and aflatoxin gene modulation

mycolabadmin

A dangerous fungus called Aspergillus flavus contaminates animal feed and produces harmful toxins called aflatoxins that can make animals sick. Researchers tested a combination of three salt-based organic acids commonly used as natural food preservatives and found they work together to kill this fungus much better than using them individually. The combination damages the fungus’s cell structure, creates harmful reactive oxygen inside the cells, and shuts down the genes that produce the toxins, making it an excellent safe option for protecting animal feed.

Microminutinin, a Fused Bis-Furan Coumarin from Murraya euchrestifolia, Exhibits Strong Broad-Spectrum Antifungal Activity by Disrupting Cell Membranes and Walls

mycolabadmin

Researchers discovered a natural compound called microminutinin from a plant used in traditional medicine. This compound shows strong ability to kill various fungal pathogens that damage crops, particularly tea plants. The compound works by breaking down the protective structures of fungal cells, making it a promising candidate for developing safer, plant-based fungicides for agriculture.

Study on the inhibitory mechanism of fig leaf extract against postharvest Fusarium in melon

mycolabadmin

Researchers discovered that fig leaves contain natural compounds that can prevent fruit rot caused by Fusarium fungus in melons. When applied to infected melons, the fig leaf extract kills the fungus by damaging its cell membranes and overwhelming it with harmful molecules called reactive oxygen species. This natural treatment could replace chemical fungicides that harm the environment and leave residues on food, offering a safer way to preserve melons during transport and storage.

Transcriptome Analysis of Dimethyl Fumarate Inhibiting the Growth of Aspergillus carbonarius

mycolabadmin

Researchers found that dimethyl fumarate, a chemical preservative, can effectively stop the growth of a common fruit fungus called Aspergillus carbonarius that causes rot and produces a harmful toxin in grapes. By studying how the fungus responds to this treatment at the genetic level, scientists discovered that the chemical damages the fungus’s protective outer layer and interferes with its ability to develop and reproduce. This research could lead to better ways to preserve fruit and prevent toxin contamination in the food industry.

Antifungal efficacy and mechanisms of Bacillus licheniformis BL06 against Ceratocystis fimbriata

mycolabadmin

Researchers discovered that a beneficial bacterium called Bacillus licheniformis BL06 can effectively prevent sweet potato black rot, a fungal disease that causes major crop losses worldwide. When applied to sweet potatoes, this bacterium reduces disease damage by interfering with the fungus’s ability to grow, form spores, and survive. The study reveals that the bacterium works by disrupting the fungus’s cell structure and energy production, making it a promising natural alternative to chemical fungicides.

In vitro and in vivo inhibitory effects and transcriptional reactions of graphene oxide on Verticillium dahliae

mycolabadmin

Scientists discovered that graphene oxide, a nanomaterial, can effectively kill or inhibit the growth of Verticillium dahliae, a harmful fungus that causes wilt disease in cotton and other crops. The graphene oxide works by damaging the fungus’s cell membranes and disrupting its ability to grow and spread. When applied to cotton plants infected with this fungus, graphene oxide treatment reduced disease symptoms and prevented the fungus from multiplying. This research suggests graphene oxide could become a valuable alternative to chemical fungicides for controlling this destructive plant disease.

In vitro biocontrol potential of plant extract-based formulation against infection structures of Phytophthora infestans along with lower non-target effects

mycolabadmin

Researchers tested a plant extract-based treatment against late blight, a serious disease affecting potatoes and tomatoes caused by Phytophthora infestans. The formulated product was highly effective at very low concentrations, stopping the disease at multiple stages of infection. Importantly, it had minimal harmful effects on beneficial microorganisms, making it a promising eco-friendly alternative to synthetic fungicides.

Screening, Identification, and Fermentation Optimization of the Antagonistic Actinomycete Strain TCS21-117 Against Botrytis cinerea

mycolabadmin

Scientists isolated a beneficial bacterium called Streptomyces roietensis from soil that effectively fights gray mold, a serious fungal disease affecting crops worldwide. They identified the strain and optimized growing conditions to maximize production of antifungal compounds, achieving 93% effectiveness against gray mold. This discovery offers a natural, environmentally-friendly alternative to chemical fungicides for protecting agricultural crops, potentially reducing crop losses and environmental pollution.

Green Synthesized Copper-Oxide Nanoparticles Exhibit Antifungal Activity Against Botrytis cinerea, the Causal Agent of the Gray Mold Disease

mycolabadmin

Scientists have developed tiny copper particles using environmentally friendly methods with beneficial fungi to fight gray mold, a devastating disease in vineyards and crops. These green-synthesized nanoparticles were more effective at stopping the fungus than commercial fungicides currently in use. The research shows this approach could be a sustainable alternative that reduces harmful chemicals used in agriculture while protecting crops more effectively.

therapeutic action: Inhibition of mycelial growth