therapeutic action: inhibition of ergosterol synthesis

Inhibitory Effects and Mechanisms of Perilla Essential Oil and Perillaldehyde against Chestnut Pathogen Botryosphaeria dothidea

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Chestnut rot caused by the fungus Botryosphaeria dothidea is a major problem during fruit storage. Researchers found that essential oil from perilla plants and its main component perillaldehyde effectively kill this fungus by damaging its cell walls and membranes. This natural solution could replace harmful synthetic fungicides while keeping chestnuts fresh longer during storage.

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Discovery of novel targets for important human and plant fungal pathogens via an automated computational pipeline HitList

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Researchers created a computer program called HitList that searches fungal DNA to find new targets for antifungal medications. The program identified 16 promising protein targets that could be attacked by new antifungal drugs, including 8 completely new targets never before considered. This discovery could help develop new antifungal treatments to fight drug-resistant fungal infections in both humans and crops.

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Antifungal Agents in the 21st Century: Advances, Challenges, and Future Perspectives

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This review examines how doctors treat serious fungal infections and the growing problem of fungi becoming resistant to medications. The authors discuss different antifungal drugs, how they work, and why some fungi are becoming harder to treat. They emphasize that controlling fungal resistance requires coordinated efforts across hospitals, farms, and communities, especially since some agricultural pesticides are creating resistant strains that spread to sick patients.

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