therapeutic action: increased terbinafine sensitivity

The Ptk2-Pma1 pathway enhances tolerance to terbinafine in Trichophyton rubrum

Researchers discovered that a protein called TrPtk2 helps dermatophytes resist terbinafine, a common antifungal medicine. They found that blocking this protein makes the fungus more susceptible to terbinafine. Additionally, they discovered that omeprazole, a stomach medication approved for human use, can be combined with terbinafine to make it more effective against resistant fungal infections.

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