Condition-dependent effects of Elexacaftor/Tezacaftor/Ivacaftor (Trikafta) on Aspergillus fumigatus growth
Researchers studied how Trikafta, a new cystic fibrosis medication, affects Aspergillus fungus growth. While Trikafta doesn’t directly kill the fungus, it makes antifungal drugs more effective and improves patients’ lung function to help clear infections naturally. However, high concentrations of the drug may reduce the immune system’s ability to fight the fungus, suggesting careful monitoring of patients is needed.