immunomodulation – Page 7

Impact of Phellinus gilvus mycelia on growth, immunity and fecal microbiota in weaned piglets

mycolabadmin

Researchers tested whether a medicinal mushroom called Phellinus gilvus could replace antibiotics in pig feed as a growth promoter. Over 28 days, piglets fed mushroom-supplemented diets grew as well as those given antibiotics while showing even better immune system activation. Unlike antibiotics that drastically changed the gut bacteria composition, the mushroom only slightly modified it while still reducing harmful E. coli bacteria. This suggests the mushroom could be a safer alternative to antibiotics in pig farming.

Biological Characteristics, Artificial Domestication Conditions Optimization, and Bioactive Components of Beauveria caledonica

mycolabadmin

Scientists successfully grew Beauveria caledonica mushrooms in a laboratory for the first time using wheat and rice as growing media. They identified the best growing conditions and found that these mushrooms contain beneficial compounds like polysaccharides and adenosine, which may have health benefits similar to traditional medicinal Cordyceps. The adenosine content was significantly higher than what is required by Chinese pharmacopoeia standards, suggesting these cultivated mushrooms could have strong medicinal value.

Modulating effects of Phellinus linteus polysaccharides on antioxidant capacity, immune function, intestinal function and microbiota in lipopolysaccharide-challenged broilers

mycolabadmin

Researchers studied how a medicinal mushroom extract called Phellinus linteus polysaccharides could help broiler chickens recover from immune stress caused by bacterial toxins. The supplement improved the chickens’ growth, reduced harmful inflammatory responses, and promoted beneficial gut bacteria while reducing harmful ones. The treatment strengthened the intestinal barrier and restored the chickens’ natural antioxidant defenses. This suggests the mushroom supplement could be a natural alternative to antibiotics for improving poultry health on farms.

Comparative transcriptome analysis reveals the genetic basis underlying the biosynthesis of polysaccharides in Hericium erinaceus

mycolabadmin

Researchers studied six different strains of lion’s mane mushrooms to understand how they produce beneficial compounds called polysaccharides. Using advanced genetic analysis, they identified thirteen key genes responsible for making these health-promoting molecules. The study found that a strain called PZH-05 produced the most polysaccharides, and its genes were more active than in other strains. This research helps explain why lion’s mane mushrooms are effective for boosting immunity, fighting cancer, and managing blood sugar.

Encapsulation of progesterone in reishi mushroom composite for optimized hormone replacement and targeted anticancer therapy

mycolabadmin

Researchers created a new treatment by combining progesterone (a hormone) with reishi mushroom powder to make it work better in the body. The mushroom acts like a protective wrapper that slowly releases the hormone, making it more effective for treating menopausal symptoms and fighting breast cancer cells. The combination also fights harmful bacteria and fungi while remaining stable during storage. This approach combines traditional medicine with modern pharmaceutical science.

Immunomodulatory natural polysaccharide-based nanoparticles for the treatment of neurodegenerative diseases

mycolabadmin

Scientists are developing tiny particles made from natural sugar-based compounds that can deliver medicine to the brain while reducing inflammation caused by neurodegenerative diseases like Alzheimer’s and Parkinson’s. These nanoparticles are special because they can cross the protective barrier surrounding the brain and carry therapeutic compounds directly to where they’re needed. The natural polysaccharides used to make these particles have built-in anti-inflammatory properties, making them safer and more effective than traditional approaches. This innovative technology shows promise for treating currently difficult-to-manage brain diseases.

Immunomodulatory activity of Pleurotus pulmonarius crude extract to human monocyte against Cryptococcus neoformans

mycolabadmin

This research shows that an extract from the Phoenix oyster mushroom (Pleurotus pulmonarius) can boost the body’s immune cells to fight dangerous fungal infections caused by Cryptococcus neoformans. When immune cells are pre-exposed to this mushroom extract and then encounter the fungus, they become more effective at killing it through increased production of immune-signaling molecules and reactive oxygen species. This natural supplement approach offers a promising alternative to traditional antifungal drugs, which often have significant side effects and can lead to drug resistance.

Exploring the Anticancer Potential of Coriolus versicolor in Breast Cancer: A Review

mycolabadmin

Coriolus versicolor, a medicinal mushroom known as Turkey tail in North America, contains special compounds that show promise in fighting breast cancer. Research shows these compounds can slow cancer cell growth, trigger cancer cell death through multiple pathways, prevent cancer spread, and boost the immune system’s ability to fight tumors. While early results are encouraging and the mushroom appears safe, more research is needed before it can be recommended as a standard breast cancer treatment.

Cordyceps militaris and Armillaria mellea formula alleviates depressive behaviors via microglia regulation in an unpredictable chronic mild stress animal model

mycolabadmin

Two medicinal mushrooms, Cordyceps militaris and Armillaria mellea, when combined as a formula, can help reduce depression-like symptoms in stressed animals. The formula works by balancing immune cells in the brain called microglia and restoring normal chemical messenger function. This treatment shows promise as a natural alternative to conventional antidepressants with fewer side effects.

The Transformation and Protein Expression of the Edible Mushroom Stropharia rugosoannulata Protoplasts by Agrobacterium-tumefaciens-Mediated Transformation

mycolabadmin

Researchers successfully developed a method to genetically modify the edible mushroom Stropharia rugosoannulata using Agrobacterium tumefaciens bacteria. This technique allows scientists to insert and express foreign genes in the mushroom, providing tools to study how specific genes control mushroom growth and the production of health-promoting compounds. The study demonstrates that both artificial and natural resistance markers can be used to identify successfully transformed mushrooms, offering a foundation for improving mushroom cultivation and breeding.

therapeutic action: immunomodulation