therapeutic action: heat shock proteins provide cellular protection

Comparative transcriptome analysis reveals the role of sugar signaling in response to high temperature stress in Armillaria gallica

Scientists studied how a fungus called Armillaria gallica responds to high heat, which is important because this fungus forms a partnership with a valuable medicinal plant called Gastrodia elata. They compared a heat-tolerant fungal strain with a heat-sensitive one and found that the heat-tolerant strain increases sugar accumulation and activates specific genes that help it survive hot conditions. Adding sucrose to the fungus’s growth medium helped it tolerate heat better, suggesting that sugar plays a key role in heat stress protection.

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iTRAQ-Based Quantitative Proteomic Analysis Reveals Proteomic Changes in Mycelium of Pleurotus ostreatus in Response to Heat Stress and Subsequent Recovery

This study examined how oyster mushrooms respond to high temperatures using advanced protein analysis techniques. Researchers found that when mushroom mycelium was exposed to 40°C heat, it damaged cell membranes and changed the levels of hundreds of proteins. However, when the temperature returned to normal, the mushrooms could repair the damage and recover. Key proteins including heat shock proteins and stress-response enzymes played important roles in protecting the mushroom cells and helping them survive heat stress.

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