growth inhibition – mycolab.ai

Chitosan-mediated copper nanohybrid attenuates the virulence of a necrotrophic fungal pathogen Macrophomina phaseolina

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Researchers developed tiny copper particles coated with chitosan (a natural compound from shellfish) that effectively kill a destructive fungus called Macrophomina phaseolina, which damages hundreds of plant species worldwide. When used at the right concentration, these nanoparticles completely stopped the fungus from growing while causing minimal damage to plants. This innovation offers a promising natural alternative to traditional chemical fungicides for protecting crops while being more environmentally friendly and sustainable.

Plants, fungi, and antifungals: A little less talk, a little more action

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Researchers propose looking at how plants communicate with fungi to discover new antifungal medicines. Plants send chemical signals to fungi, and understanding these signals could help us develop better treatments for fungal infections in humans and crops. By studying a simple yeast model, scientists found that plant molecules called strigolactones control fungal phosphate metabolism, suggesting they could become new drug targets.

Hass Avocado (Persea americana Mill) Peel Extract Reveals Antimicrobial and Antioxidant Properties against Verticillium theobromae, Colletotrichum musae, and Aspergillus niger Pathogens Affecting Musa acuminata Colla Species, in Ecuador

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Researchers tested whether avocado peel waste could help protect banana crops from fungal diseases. They extracted beneficial compounds from avocado peels and tested them against three harmful fungi that affect bananas. The results showed the extract worked best against one type of fungus and had good antioxidant properties, suggesting avocado peel could be a natural and sustainable way to protect banana crops.

Essential Oils as an Antifungal Alternative for the Control of Various Species of Fungi Isolated from Musa paradisiaca: Part I

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Researchers tested six essential oils from common kitchen herbs to see if they could prevent banana spoilage caused by fungi. They found that cinnamon oil was especially effective, stopping fungal growth at relatively low concentrations. This research suggests that natural essential oils could replace harsh chemical fungicides in farming, making bananas safer for consumers and better for the environment.

Investigation of the antifungal activity of panobinostat, tamoxifen, and miltefosine alone and in combination with some conventional antifungal drugs against fluconazole-resistant Candida species

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Researchers tested whether three cancer drugs (panobinostat, tamoxifen, and miltefosine) could enhance the effectiveness of common antifungal medications against drug-resistant yeast infections. When combined with antifungals, some of these cancer drugs showed promise in killing resistant Candida species, though the effectiveness varied depending on which type of yeast was being treated. These findings suggest that combination therapies using already-approved drugs could help treat difficult fungal infections in cancer patients.

In Vitro Screening of the Antifungal and Antimycotoxin Effects of a Stilbenoids-Rich Grapevine Cane Extract on Fusarium graminearum, Aspergillus flavus and Penicillium expansum

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This study tested a natural extract from grapevine pruning waste to see if it could stop three dangerous fungi that produce harmful toxins in crops. The extract worked well at stopping both fungal growth and toxin production, with effects that lasted even after the extract was removed. These results suggest that grapevine waste could be turned into a natural fungicide to protect crops from contamination.

Superhydrophobic Fatty Acid-Based Spray Coatings with Dual-Mode Antifungal Activity

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Scientists developed easy-to-apply spray coatings made from natural fatty acids that repel water and kill fungal infections like gray mold. By combining long-chain fatty acids with shorter fatty acids like those found in food preservatives, the coatings can either passively prevent fungus from sticking to surfaces or actively kill it. These coatings are environmentally friendly, sustainable alternatives to chemical fungicides that fungi are becoming resistant to, and could be used to protect everything from building surfaces to stored crops.

Antifungal Activity of Genistein Against Phytopathogenic Fungi Valsa mali Through ROS-Mediated Lipid Peroxidation

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Scientists discovered that genistein, a natural compound found in soybeans and other legumes, can effectively kill the fungus that causes apple tree canker disease. The compound works by creating harmful reactive oxygen species that damage the fungus’s cell membranes and disrupt its normal cellular functions. This research suggests genistein could be developed as a safe, natural alternative to chemical fungicides for protecting apple crops.

Exploring the Antifungal Potential of Lawsone-Loaded Mesoporous Silica Nanoparticles Against Candida albicans and Candida glabrata: Growth Inhibition and Biofilm Disruption

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Researchers developed a new antifungal treatment by loading lawsone (a compound from henna plants) into tiny particles called mesoporous silica nanoparticles. When tested against common fungal infections caused by Candida bacteria, this nano-formulation was more effective than lawsone alone at killing the fungi and breaking down protective biofilm structures. The treatment showed no harm to normal human cells, suggesting it could be a promising natural alternative to treat stubborn fungal infections that resist current antifungal drugs.

A novel pan-fungal screening platform for antifungal drug discovery: proof of principle study

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Researchers developed a faster, more efficient screening method to test potential antifungal drugs against multiple disease-causing fungi simultaneously. Using an improved growth medium and screening 500 chemical fragments, they identified compounds with antifungal activity and demonstrated the platform can reliably detect promising drug candidates. This approach could accelerate the discovery of new antifungal medications, which are urgently needed as fungi develop resistance to current treatments.

therapeutic action: growth inhibition