Recalcitrant dermatophytosis due to Trichophyton indotineae: A case series from Sarawak, Malaysia
mycolabadmin
Three patients in Malaysia had persistent skin fungal infections caused by Trichophyton indotineae that did not respond to standard antifungal treatments. Genetic testing revealed these fungal strains carried a specific mutation making them resistant to terbinafine, the typical first-line treatment. While azole-based antifungals showed variable effectiveness depending on the specific drug and dose used, one patient achieved complete cure with voriconazole therapy. The study highlights the growing problem of drug-resistant fungal infections and the importance of targeted treatment based on laboratory testing.