fungicidal activity – mycolab.ai

Inhibitory Activity of Shrimp Waste Extracts on Fungal and Oomycete Plant Pathogens

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Researchers discovered that waste from shrimp processing can be converted into a natural fungicide that effectively kills plant-damaging fungi and mold. When applied to oranges, lemons, and apples artificially infected with mold, the shrimp waste extract significantly reduced rot and fruit damage. This finding is important because it offers a more environmentally friendly alternative to chemical fungicides while helping reduce the massive amounts of shrimp processing waste that typically end up in landfills or oceans.

Synthesis of silver nanoparticles employing Polyalthia longifolia leaf extract and their in vitro antifungal activity against phytopathogen

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Scientists successfully created tiny silver particles using leaves from the Polyalthia longifolia plant, an evergreen tree native to India. These silver nanoparticles proved highly effective at stopping the growth of Alternaria alternata, a fungus that damages crops and causes leaf spot disease. The method is inexpensive, environmentally friendly, and the particles remain stable for months, making them a promising natural alternative to chemical fungicides for protecting plants.

Pathogen identification and biological fungicides screening for Plumbago auriculata blight in China

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A newly identified fungal disease caused by Fusarium ipomoeae is harming Plumbago auriculata plants in China. Scientists identified the pathogen using genetic analysis and tested seven plant-based treatments. They found that osthole, a natural compound, effectively controls the disease with 88% success rate, offering an environmentally friendly solution for protecting ornamental plants.

Efficacy assessments of SF001, a next-generation polyene antifungal, in a neutropenic mouse model of invasive fusariosis

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This study tested a new antifungal drug called SF001 against a serious infection called fusariosis in mice. SF001 performed as well as the current standard treatment (amphotericin B) but with better safety profiles. The drug successfully reduced fungal infections in organs and improved survival rates in infected mice without showing signs of toxicity at higher doses.

In vitro and in vivo efficacy of the antimycobacterial molecule SQ109 against the human pathogenic fungus, Cryptococcus neoformans

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Researchers discovered that SQ109, an antimycobacterial drug, can effectively kill Cryptococcus fungi that cause serious brain infections in people with weakened immune systems. Unlike current treatments, cryptococcal cells don’t easily develop resistance to SQ109, and it works even better when combined with fluconazole. In mouse studies, SQ109 successfully treated cryptococcal infections, suggesting it could be a valuable new treatment option for patients worldwide, especially in resource-limited regions.

Past, present and future of antifungals: Advancements in mechanisms of action and resistance

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Fungal infections are a growing global health threat, especially for people with weakened immune systems, causing millions of deaths annually. Currently available antifungal drugs are limited and increasingly face resistance, making them less effective over time. This special collection of research papers explores new approaches to treating fungal infections, including novel drugs, combination therapies, and alternative treatments to overcome resistance. Scientists and doctors hope these advances will help save more lives by providing better options for treating serious fungal diseases.

Evaluation of antifungal effect of amphotericin B in comparison with nystatin on Candida species derived from patients undergoing head-and-neck radiotherapy

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This study compared two antifungal medications (nystatin and amphotericin B) for treating oral yeast infections in cancer patients receiving head-and-neck radiotherapy. Researchers tested how well each drug worked against different Candida yeast species before and during radiation treatment. The results showed that nystatin was more effective than amphotericin B at killing the yeasts, with nystatin working against all yeast species tested, while amphotericin B had reduced effectiveness against some Candida albicans strains.

Synthesis, Physicochemical Properties and Anti-Fungal Activities of New Meso-Arylporphyrins

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Researchers created three new porphyrin compounds that effectively kill fungal infections like Candida and athlete’s foot fungi. These compounds can also generate singlet oxygen when exposed to light, making them potentially useful for photodynamic therapy treatments. Testing showed they inhibited fungal growth at relatively low concentrations, suggesting they could become new antifungal medications.

Caspofungin therapy in prosthetic valve endocarditis and candidemia due to itraconazole-resistant Candida glabrata (Nakaseomyces glabratus): A case report

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A 13-year-old boy developed a serious fungal infection on his replacement heart valve after recent surgery. The fungal infection was caused by a type of yeast called Candida glabrata that was resistant to the initial antifungal medication. After testing revealed resistance and biofilm formation, doctors switched to caspofungin, a stronger antifungal drug, and the patient recovered successfully.

The serine palmitoyl transferase of plant pathogenic fungi: a promising new target for the development of novel crop protection solutions

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Scientists have discovered a new type of fungicide called pyridazine carboxamides that effectively kill plant-damaging fungi by blocking a key enzyme involved in their cell membrane formation. These compounds work against many common crop diseases like gray mold and leaf spots, though they are less effective against certain wheat pathogens. The research validates this new approach as a promising tool for protecting crops and managing fungicide resistance while maintaining global food security.

therapeutic action: fungicidal activity