therapeutic action: fungal growth suppression

The Global Secondary Metabolite Regulator AcLaeA Modulates Aspergillus carbonarius Virulence, Ochratoxin Biosynthesis, and the Mode of Action of Biopesticides and Essential Oils

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Grapes can be infected with a fungus called Aspergillus carbonarius that produces a dangerous toxin called ochratoxin A. Scientists studied a regulatory gene called AcLaeA that controls toxin production in this fungus. By deleting this gene, the fungus became less virulent and produced much less toxin. Natural products like cinnamon and thyme oils, along with commercial biocontrol products, were found to reduce toxin production by suppressing this regulatory gene, offering promising natural alternatives to chemical fungicides.

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Transcriptome Analysis of Dimethyl Fumarate Inhibiting the Growth of Aspergillus carbonarius

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Researchers studied how a chemical called dimethyl fumarate stops the growth of a dangerous fungus (Aspergillus carbonarius) that damages grapes and produces a toxin called ochratoxin A. By analyzing which genes were turned on and off when the fungus was exposed to this chemical, they found that it works by damaging the fungus’s cell walls and disrupting its normal development. This discovery could help protect fruit crops and food safety by providing a natural and non-toxic way to prevent mold growth.

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Extracellular Biosynthesis, Characterization and Antimicrobial Activity of Silver Nanoparticles Synthesized by Filamentous Fungi

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Researchers used three types of common fungi to create tiny silver particles in an environmentally friendly way. These silver nanoparticles were found to effectively kill harmful bacteria and fungal infections. The fungus Cladosporium cladosporoides was the most effective at producing these particles, showing promise for use in medical and health applications.

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A broad-spectrum anti-fungal effector dictates bacterial-fungal interkingdom interactions

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Scientists discovered that a common soil bacterium called Acidovorax citrulli has a sophisticated weapon to fight dangerous fungi. This bacterium uses a needle-like structure to inject a toxic protein called TseN directly into fungal cells, where it damages the fungal DNA and causes death. This new discovery is particularly exciting because it works against drug-resistant fungi like Candida auris that are increasingly hard to treat. Tests in mice confirmed that this bacterial attack significantly reduces fungal infections on skin.

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