fungal growth inhibition – Page 4

Current Approaches to Aflatoxin B1 Control in Food and Feed Safety: Detection, Inhibition, and Mitigation

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Aflatoxins are poisonous substances made by certain molds that contaminate about a quarter of the world’s food supply and are known carcinogens. This review examines the latest methods for detecting these toxins (from simple lab tests to advanced smartphone-powered devices) and ways to remove or prevent them, including using beneficial bacteria and special plasma treatment. The research shows that combining multiple approaches—detection technology with biological solutions—works best for keeping our food and animal feed safe from these dangerous contaminants.

Improving treatment of chromoblastomycosis: the potential of COP1T-HA and antimicrobial photodynamic therapy against Fonsecaea monophora in vitro

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Chromoblastomycosis is a stubborn skin fungal infection that is difficult to treat with current medications and often comes back after treatment. Researchers tested a new treatment using a special light-activated compound called COP1T-HA combined with blue light, which successfully killed the fungus in laboratory tests. The treatment worked quickly and at low doses, showing promise as a potential new therapy for this challenging infection.

Complete genome analysis and antimicrobial mechanism of Bacillus velezensis GX0002980 reveals its biocontrol potential against mango anthracnose disease

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Researchers discovered a beneficial bacterium called Bacillus velezensis that can prevent mango rot caused by a destructive fungus. This bacterium produces natural antimicrobial compounds that kill the disease-causing fungus without the need for harmful chemical pesticides. When applied to mangoes, it reduced disease by 52% and extended the fruits’ shelf life, offering a safe and environmentally friendly solution for protecting mangoes after harvest.

Antifungal activity of zinc oxide nanoparticles (ZnO NPs) on Fusarium equiseti phytopathogen isolated from tomato plant in Nepal

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Researchers in Nepal isolated a fungus called Fusarium equiseti that damages tomato plants and created tiny zinc oxide particles from tea leaves to fight it. These nanoparticles successfully stopped the fungus from growing, reducing its growth by up to 85%. This discovery offers farmers an environmentally friendly alternative to chemical fungicides that harm the environment and create resistant fungi.

Characterization of a bacterial strain T226 and its efficacy in controlling post-harvest citrus anthracnose

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Scientists discovered a beneficial bacterium called Lysobacter enzymogenes (strain T226) that effectively controls anthracnose, a fungal disease affecting citrus fruits after harvest. This bacterium was isolated from soil and shows strong ability to inhibit the disease-causing fungus while remaining stable over time. The research demonstrates that this biological control agent could be a promising eco-friendly alternative to chemical fungicides for protecting stored citrus fruits.

Addressing filamentous fungi-related onychomycosis in the era of antifungal resistance: assessment of Zataria multiflora nanostructured lipid carrier topical gel in a double-blinded clinical trial

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Nail fungal infections (onychomycosis) are difficult to treat, especially as fungi become resistant to standard antifungal medications. Researchers tested a new gel made from Zataria multiflora (Shirazi thyme) packaged in special nanoparticles that help the medicine penetrate the nail better. In a clinical trial comparing this gel to placebo, the Zataria multiflora treatment showed better results after just 2 weeks, with 70% of patients experiencing fungal cure compared to 55% with placebo.

Superhydrophobic Fatty Acid-Based Spray Coatings with Dual-Mode Antifungal Activity

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Researchers developed special water-repellent coatings made from natural fatty acids that can prevent fungal infections. These coatings work in two ways: they physically prevent fungi from sticking to surfaces through their bumpy structure, and they chemically kill fungi that do land on them. The coatings can be easily sprayed on like paint and offer an environmentally friendly alternative to traditional antifungal treatments that are becoming less effective.

Safety and Efficacy of a 48-Month Efinaconazole 10% Solution Treatment/Maintenance Regimen: 24-Month Daily Use Followed by 24-Month Intermittent Use

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Researchers studied a 4-year treatment plan for toenail fungal infections using efinaconazole, an antifungal solution applied daily for 2 years, then 2-3 times weekly for another 2 years. The treatment was safe and effective, with all patients who achieved a cure maintaining it through the maintenance phase, and even some non-cured patients improving further. The study included many elderly patients, showing the treatment is safe across all age groups and could help prevent infection relapse.

Rhinocerebral Mucormycosis in a Patient With Diabetes: A Rare but Critical Infection in the United Arab Emirates

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A middle-aged man with undiagnosed diabetes developed a serious fungal infection called mucormycosis that affected his sinuses, eyes, and brain. He presented with flu-like symptoms and facial weakness, and blood tests showed dangerously high blood sugar and acid levels (diabetic ketoacidosis). Doctors treated him with multiple rounds of antifungal medications, several surgeries, and innovative injections directly into and around his eyes and spinal cord, resulting in his successful recovery and discharge.

Antifungal Activity of Selected Naphthoquinones and Their Synergistic Combination with Amphotericin B Against Cryptococcus neoformans H99

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Scientists tested five synthetic compounds called naphthoquinones to see if they could fight a serious fungal infection called cryptococcosis. They found that one compound called 2-MNQ worked well against the fungus and was even more effective when combined with a standard antifungal drug (amphotericin B). The combination was strong enough to potentially allow lower doses of the existing drug, which could reduce side effects while improving treatment outcomes.

therapeutic action: fungal growth inhibition