therapeutic action: fungal cell wall disruption

Improving the production of micafungin precursor FR901379 in Coleophoma empetri using heavy-ion irradiation and its mechanism analysis

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Researchers used heavy-ion radiation to create improved strains of a fungus that produces a precursor to micafungin, an important antifungal drug. The improved strains produced over 3.5 times more of the desired compound than the original strain. By analyzing the genetic changes in these improved strains, the scientists identified which genes were most important for boosting production, helping guide future improvements in manufacturing this life-saving medicine.

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Identification and antifungal susceptibility patterns of reference yeast strains to novel and conventional agents: a comparative study using CLSI, EUCAST and Sensititre YeastOne methods

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Researchers compared three different laboratory methods for testing how well antifungal drugs work against common yeast infections. They tested 22 different yeast strains including Candida species using CLSI, EUCAST, and Sensititre YeastOne methods. The methods showed strong agreement overall, but some newer antifungal drugs like ibrexafungerp showed more variation between methods. The findings suggest these methods are reliable for guiding treatment decisions, but further standardization is needed for newer drugs.

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Improving the production of micafungin precursor FR901379 in Coleophoma empetri using heavy-ion irradiation and its mechanism analysis

mycolabadmin

Scientists successfully improved the production of a key ingredient for the antifungal drug micafungin by using heavy-ion radiation to create improved strains of a fungus called Coleophoma empetri. The best mutant strain produced over 250% more of the desired compound than the original strain. By analyzing the genetic changes in these improved strains, researchers identified specific genes related to fungal structure and metabolism that contribute to higher production, providing insights for future improvements to the manufacturing process.

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Pathogen identification and biological fungicides screening for Plumbago auriculata blight in China

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Researchers identified a fungal pathogen (Fusarium ipomoeae) causing a serious disease in Plumbago auriculata ornamental plants in China. They tested seven biological fungicides and found that osthole was the most effective at preventing the disease. The study provides gardeners and farmers with an environmentally friendly solution to control this plant disease using a natural compound.

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