therapeutic action: fear extinction

Psychedelic iatrogenic structural dissociation: an exploratory hypothesis on dissociative risks in psychedelic use

This paper explores potential risks of psychedelic use in people who have experienced trauma, proposing that psychedelics might reactivate unprocessed traumatic memories and cause psychological instability. The authors suggest that while psychedelics show promise for treating depression and PTSD, people with trauma histories need careful screening and support before, during, and after use. They recommend body-focused therapies and strong social support to help safely integrate traumatic material that might surface during psychedelic experiences.

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Psilocybin-assisted massed cognitive processing therapy for chronic posttraumatic stress disorder: Protocol for an open-label pilot feasibility trial

This study tests whether psilocybin (a psychedelic compound) combined with intensive therapy can help treat chronic PTSD better than therapy alone. Fifteen patients with PTSD will receive one dose of psilocybin alongside 12 therapy sessions completed over a single week. Researchers will track feasibility, safety, symptom improvements, and use wearable devices to monitor physiological changes. The results will help determine whether larger trials should test this innovative combination therapy.

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