Researchers reviewed eight studies examining whether psilocybin, a naturally occurring psychedelic compound found in certain mushrooms, could treat various types of headaches and migraines. Most studies found that psilocybin provided clinically significant relief, with participants experiencing improvements in how often they got headaches, how intense they were, and how long they lasted. However, some users experienced side effects like hallucinations or temporary increases in anxiety, and the compound remains illegal in most countries, limiting current research.