therapeutic action: enhanced solubility

Functional Approaches to Discover New Compounds via Enzymatic Modification: Predicted Data Mining Approach and Biotransformation-Guided Purification

Scientists are developing faster ways to discover new medicines from plants using two innovative methods. The first approach uses computer programs to predict which plant compounds can be chemically modified by enzymes to create new medicines with better properties. The second approach combines enzyme chemistry with traditional purification to directly isolate these modified compounds from plant extracts. These methods have successfully created new compounds with improved effectiveness against diseases like diabetes and cancer, often with much better solubility for medical use.

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Formulation, characterization, and in vitro antifungal evaluation of liposomal terbinafine prepared by the ethanol injection method

Researchers developed a new way to deliver the antifungal drug terbinafine using tiny fat-based particles called liposomes. These particles are designed to carry the drug more effectively to infected tissues while reducing harmful side effects. The optimized formulation showed promise for treating stubborn fungal infections, especially those affecting the brain, with significantly reduced toxicity compared to the drug alone.

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