therapeutic action: disruption of cell membrane integrity

Efficacy of Trichoderma longibrachiatum SC5 Fermentation Filtrate in Inhibiting the Sclerotinia sclerotiorum Growth and Development in Sunflower

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Scientists studied a beneficial fungus called Trichoderma longibrachiatum that can fight a harmful mold (Sclerotinia sclerotiorum) which damages sunflower crops. They discovered that liquid containing products from this beneficial fungus can significantly stop the harmful mold from growing, prevent it from forming protective survival structures called sclerotia, and reduce its ability to infect plants. When tested on sunflower leaves, this fungal liquid was highly effective at both preventing disease before infection and stopping disease after infection had started.

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Plants, fungi, and antifungals: A little less talk, a little more action

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Plants and fungi communicate through small chemical molecules, and scientists are discovering that understanding this dialogue could lead to new antifungal medicines. Researchers found that a plant hormone called strigolactone affects a specific fungal protein involved in nutrient uptake, suggesting this could be a target for new drugs. By using baker’s yeast as a laboratory model, scientists can study how fungal cells respond to plant chemicals and identify new ways to fight dangerous fungal infections that are becoming resistant to current treatments.

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The Antimicrobial Extract Derived from Pseudomonas sp. HP-1 for Inhibition of Aspergillus flavus Growth and Prolongation of Maize Seed Storage

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Researchers discovered that a beneficial bacterium called Pseudomonas sp. HP-1 can produce a natural compound that effectively prevents mold contamination in stored maize seeds. The extract from this bacterium showed strong antifungal activity against Aspergillus flavus, a major cause of aflatoxin contamination in grain storage. The main protective compound was identified as phenazinecarboxylic acid, which works by damaging the cell membranes of fungal cells. This finding offers a promising eco-friendly alternative to synthetic chemical fungicides for protecting stored crops.

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In vitro and in vivo inhibitory effects and transcriptional reactions of graphene oxide on Verticillium dahliae

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Graphene oxide, a nanomaterial derived from graphene, effectively inhibits the growth of Verticillium dahliae, a fungus that causes devastating wilt disease in cotton and many other plants. The study shows that graphene oxide damages the fungal cell membrane and disrupts key metabolic processes, preventing the fungus from growing and infecting plants. When applied to cotton plants, graphene oxide treatment significantly reduced wilt disease symptoms, suggesting it could be a promising alternative to chemical fungicides for controlling this important agricultural disease.

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