therapeutic action: cytotoxicity against cancer cells

Biosynthesis of mushroom-derived type II ganoderic acids by engineered yeast

Scientists successfully engineered baker’s yeast to produce ganoderic acids, potent anti-cancer compounds from medicinal mushrooms, at much higher levels than found in farmed mushrooms. By identifying key enzymes responsible for converting simpler compounds into active ganoderic acids, researchers created yeast strains that produce these valuable compounds 100-10,000 times more efficiently than traditional mushroom farming. This breakthrough could make these expensive medicinal compounds more accessible and affordable for medical research and potential drug development.

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Changes in Functionality of Tenebrio molitor Larvae Fermented by Cordyceps militaris Mycelia

Scientists fermented mealworms (a sustainable food source) with a medicinal fungus called Cordyceps militaris to make them more nutritious and appealing. The fermented mealworms had much higher protein, fiber, and a cancer-fighting compound called cordycepin compared to regular mealworms. This technique creates a healthier, more environmentally friendly alternative protein food that could help feed growing populations while reducing the environmental impact of traditional livestock farming.

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Physicochemical Characteristics of Chitosan Extracted from Pleurotus ostreatus and Its Anticancer Activity Against the MDA-MB-231 Breast Cancer Cell Line

Researchers extracted a compound called chitosan from oyster mushrooms (Pleurotus ostreatus) and tested its ability to fight breast cancer cells. The chitosan successfully killed cancer cells by triggering apoptosis, a natural cell death process, while showing promise as a safer alternative to conventional chemotherapy. The study demonstrates that mushroom-derived compounds could have significant therapeutic potential for cancer treatment with fewer side effects than traditional drugs.

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Chemical Characterization and In Vitro Antioxidant, Anti-Inflammatory, and Colon Cancer-Preventive Potential of a Polysaccharide Fraction from Macrolepiota procera

Researchers isolated special sugar compounds called polysaccharides from parasol mushrooms and tested their health benefits. These compounds were found to fight free radicals that damage cells, reduce inflammation in the body, and specifically kill colon cancer cells while leaving healthy cells unharmed. The study suggests that parasol mushrooms could be developed into health supplements or functional foods to help prevent cancer and improve overall health.

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