therapeutic action: Cytokine reduction

The Effect of Combined Treatment of Psilocybin and Eugenol on Lipopolysaccharide-Induced Brain Inflammation in Mice

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This study tested whether psilocybin (an active compound from magic mushrooms) combined with eugenol (a natural compound from cloves) could reduce brain inflammation in mice. Researchers gave mice a substance that triggers inflammation in the brain and then treated them with these compounds before or after the inflammation started. The combination treatment, especially at a 1:50 ratio of psilocybin to eugenol, significantly reduced multiple inflammatory markers in the brain, suggesting this combination could potentially be helpful for treating brain inflammation-related conditions.

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Armillaria mellea Mycelia Alleviate PM2.5-Induced Pulmonary Inflammation in Murine Models

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This study found that Armillaria mellea mushroom mycelia can help protect lungs from damage caused by PM2.5 air pollution. When tested in both laboratory cells and mice, the mushroom extract reduced inflammatory responses and restored healthy lung function. The protective effects work by reducing harmful inflammatory molecules and blocking inflammatory signaling pathways. These findings suggest A. mellea could be developed into a natural supplement to help protect respiratory health in areas with poor air quality.

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