therapeutic action: cognitive improvement

Exploring psychedelic use in athletes and their attitudes toward psilocybin-assisted therapy in concussion recovery

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This study surveyed athletes and sports staff in Canada and the United States about their views on using psilocybin-assisted therapy to treat concussion symptoms. Researchers found that about 36% of athletes had used psychedelics in the past year, with psilocybin being the most common. Most athletes (61%) and staff (71%) said they would be willing to try or support psilocybin therapy for concussion recovery if research showed it was beneficial. The main factor influencing willingness was knowledge about psilocybin and positive attitudes toward it.

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Assessment of Lab4P Probiotic Effects on Cognition in 3xTg-AD Alzheimer’s Disease Model Mice and the SH-SY5Y Neuronal Cell Line

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Researchers tested a probiotic supplement called Lab4P on mice genetically engineered to develop Alzheimer’s-like symptoms and on human brain cells exposed to damaging proteins. The supplement successfully improved memory and cognitive function in the mice while protecting brain cells from damage, with stronger benefits when the mice were also on a high-fat diet. These findings suggest that probiotics might help prevent or slow cognitive decline related to Alzheimer’s disease.

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Erythropoietin restrains the inhibitory potential of interneurons in the mouse hippocampus

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Researchers studied how a protein called erythropoietin (EPO) affects brain cells called interneurons in the hippocampus, a region important for memory and learning. They found that EPO treatment reduces the inhibitory activity of certain interneurons, which makes the brain’s excitatory neurons more active. This change in brain balance could potentially help treat psychiatric disorders like schizophrenia and autism that involve imbalanced brain activity.

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Reprogramming astrocytic NDRG2/NF-κB/C3 signaling restores the diabetes-associated cognitive dysfunction

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This study found that regular exercise helps protect the brain of diabetic people from cognitive decline by boosting a protein called NDRG2 in astrocytes (brain support cells). The research shows that NDRG2 works by blocking harmful immune responses that damage synapses (connections between brain cells). In diabetic mice, exercise improved memory and learning ability while increasing NDRG2 levels, while blocking this protein reversed these benefits.

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