therapeutic action: cognitive function improvement

Long-COVID symptoms improved after MDMA and psilocybin therapy: A case report

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A 41-year-old woman with Long-COVID experienced severe symptoms including fatigue, depression, anxiety, headaches, and brain fog that didn’t improve with traditional treatments. She decided to try psilocybin mushrooms and MDMA with guidance from a therapist. After multiple dosing sessions over several months, she reported roughly 80-90% improvement in her symptoms and was able to return to work and resume her studies. While this single case is promising, more research is needed to determine whether these psychedelics are truly safe and effective for Long-COVID.

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Efficacy and safety of MT104, a dietary supplement based on Cuscuta seeds and heat‐killed probiotics, on cognitive function in patients with mild cognitive impairment: A 12‐week, multicenter, randomized, double‐blind, placebo‐controlled clinical trial

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Researchers tested a dietary supplement called MT104 made from Cuscuta seeds and special probiotics to see if it could improve memory and thinking in people with mild cognitive impairment, an early stage before dementia develops. In a 12-week study with 200+ participants, those taking MT104 showed better memory recall and overall cognitive function compared to those taking a placebo. The supplement appeared to be safe with no serious side effects, suggesting it could be a helpful natural approach to slow the progression toward Alzheimer’s disease.

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Insights into the special physiology of Mortierella alpina cultured by agar supported solid state fermentation in enhancing arachidonic acid enriched lipid production

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Researchers developed a new fermentation method using agar plates to grow a fungus called Mortierella alpina that produces arachidonic acid, an important nutrient used in medicines and supplements. This method produced significantly more arachidonic acid than traditional liquid fermentation while being more environmentally friendly. By understanding how the fungus grows differently on agar plates, they optimized the production process to achieve even higher yields, making this approach promising for commercial production.

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Benefits, side effects, and uses of Hericium erinaceus as a supplement: a systematic review

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Lion’s Mane mushroom shows promising benefits for brain health, potentially improving memory and reducing symptoms of anxiety and depression. It may help prevent cancer by triggering cancer cell death and supports digestive health by promoting beneficial gut bacteria. While generally safe, some people experience mild side effects like stomach discomfort or headaches, making it an accessible supplement for overall wellness.

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Butyrate ameliorates quinolinic acid–induced cognitive decline in obesity models

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This research shows that overweight and obese individuals have higher levels of a toxic compound called quinolinic acid in their bodies, which is linked to memory problems and brain shrinkage. The good news is that butyrate, a substance naturally produced by gut bacteria when we eat fiber, can protect against these harmful effects. Butyrate works by activating genes that produce brain-derived neurotrophic factor (BDNF), a protein essential for brain health and memory formation. The study suggests that increasing butyrate through diet or supplements could help prevent cognitive decline associated with obesity.

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The progress of the microbe-gut-brain axis in sepsis-associated encephalopathy

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Sepsis can cause brain dysfunction called sepsis-associated encephalopathy, leading to memory problems and confusion in about one-third to two-thirds of sepsis patients. The bacteria in your gut communicate with your brain through multiple pathways, and when sepsis disrupts this communication, it causes harmful inflammation in the brain. Treatments like probiotics and transplanting healthy gut bacteria from donors show promise in animal studies and early human trials for improving memory and cognitive function after sepsis.

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Influences of substrate and tissue type on erinacine production and biosynthetic gene expression in Hericium erinaceus

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Researchers studied how different growing conditions affect erinacine production in lion’s mane mushroom mycelium. They found that the type of nutrients provided (substrate) significantly influences which erinacines are produced, even when the genes responsible for making these compounds show similar activity levels. Mycelium produced much more erinacines than fruit bodies, and specific nutrients could be used to encourage production of specific beneficial compounds.

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